ENSMUSG00000037286


Mus musculus

Features
Gene ID: ENSMUSG00000037286
  
Biological name :Stag1
  
Synonyms : Cohesin subunit SA-1 / Q9D3E6 / Stag1
  
Possible biological names infered from orthology : Q8WVM7 / stromal antigen 1
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.3
Gene start: 100597798
Gene end: 100959375
  
Corresponding Affymetrix probe sets: 10588154 (MoGene1.0st)   1421939_a_at (Mouse Genome 430 2.0 Array)   1421940_at (Mouse Genome 430 2.0 Array)   1431921_a_at (Mouse Genome 430 2.0 Array)   1434189_at (Mouse Genome 430 2.0 Array)   1441724_at (Mouse Genome 430 2.0 Array)   1450420_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116597
Ensembl peptide - ENSMUSP00000123595
Ensembl peptide - ENSMUSP00000120974
Ensembl peptide - ENSMUSP00000119637
Ensembl peptide - ENSMUSP00000118952
Ensembl peptide - ENSMUSP00000117879
Ensembl peptide - ENSMUSP00000040724
Ensembl peptide - ENSMUSP00000115460
Ensembl peptide - ENSMUSP00000116205
Ensembl peptide - ENSMUSP00000116322
NCBI entrez gene - 20842     See in Manteia.
MGI - MGI:1098658
RefSeq - XM_017313258
RefSeq - NM_009282
RefSeq - XM_006510923
RefSeq - XM_006510924
RefSeq - XM_006510925
RefSeq - XM_006510927
RefSeq - XM_011242692
RefSeq Peptide - NP_033308
swissprot - D6RHQ7
swissprot - Q8C918
swissprot - Q9D3E6
swissprot - D6REF2
swissprot - D3Z1T1
swissprot - D3YYD4
swissprot - F6TNY1
swissprot - F6XQW1
swissprot - D6RH50
swissprot - F8WHU7
Ensembl - ENSMUSG00000037286
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stag1aENSDARG00000061205Danio rerio
 stag1bENSDARG00000062137Danio rerio
 STAG1ENSGALG00000035116Gallus gallus
 STAG1ENSG00000118007Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stag2 / O35638 / stromal antigen 2 / Q8N3U4*ENSMUSG0000002586270
Stag3 / O70576 / Cohesin subunit SA-3 / Q9UJ98* / stromal antigen 3*ENSMUSG0000003692845


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR013721  STAG
 IPR016024  Armadillo-type fold
 IPR020839  Stromalin conservative domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1901673 regulation of mitotic spindle assembly IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0008278 cohesin complex IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0097431 mitotic spindle pole IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids
Establishment of Sister Chromatid Cohesion
Cohesin Loading onto Chromatin
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0001780 decreased brown fat amount "reduced quantity of this thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0002014 papilloma "benign epithelial tumor" [J:47225]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0003420 delayed intramembranous bone ossification "late onset of bone formation in bones that form without a cartilagenous intermediate including the cranium and clavicle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0004754 abnormal kidney collecting duct "any structural anomaly of the duct that drains fluid from the nephron and either allows bodily reabsorbtion of water or allows the fluid to drain to the bladder via the ureter; the collecting duct system also maintains acid-base homeostasis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0010207 abnormal telomere morphology "any structural anomaly of the terminal repetitive DNA section of a chromosome which is involved in chromosomal replication and senescence, and which protects the end of the chromosome from deterioration" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: ApcMin/Apc+,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Stag1Gt(P099A04)Wrst/Stag1+
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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