ENSG00000118007


Homo sapiens

Features
Gene ID: ENSG00000118007
  
Biological name :STAG1
  
Synonyms : Q8WVM7 / STAG1 / stromal antigen 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q22.3
Gene start: 136336233
Gene end: 136752403
  
Corresponding Affymetrix probe sets: 202293_at (Human Genome U133 Plus 2.0 Array)   202294_at (Human Genome U133 Plus 2.0 Array)   232588_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420789
Ensembl peptide - ENSP00000419317
Ensembl peptide - ENSP00000486745
Ensembl peptide - ENSP00000236698
Ensembl peptide - ENSP00000372689
Ensembl peptide - ENSP00000404396
Ensembl peptide - ENSP00000418472
Ensembl peptide - ENSP00000419093
NCBI entrez gene - 10274     See in Manteia.
OMIM - 604358
RefSeq - XM_017005525
RefSeq - NM_005862
RefSeq - XM_011512329
RefSeq - XM_011512331
RefSeq - XM_017005523
RefSeq - XM_017005524
RefSeq Peptide - NP_005853
swissprot - Q8WVM7
swissprot - F8WCB3
swissprot - Q68DW7
swissprot - H7C595
swissprot - C9JJQ0
swissprot - F8WF82
Ensembl - ENSG00000118007
  
Related genetic diseases (OMIM): 617635 - Mental retardation, autosomal dominant 47, 617635
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stag1aENSDARG00000061205Danio rerio
 stag1bENSDARG00000062137Danio rerio
 STAG1ENSGALG00000035116Gallus gallus
 Stag1ENSMUSG00000037286Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STAG2 / Q8N3U4 / stromal antigen 2ENSG0000010197270
STAG3 / Q9UJ98 / stromal antigen 3ENSG0000006692347


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR013721  STAG
 IPR016024  Armadillo-type fold
 IPR020839  Stromalin conservative domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1901673 regulation of mitotic spindle assembly IMP
 cellular_componentGO:0000775 chromosome, centromeric region TAS
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005694 chromosome TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0008278 cohesin complex IDA
 cellular_componentGO:0016363 nuclear matrix IDA
 cellular_componentGO:0016604 nuclear body IDA
 cellular_componentGO:0097431 mitotic spindle pole IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Meiotic synapsis
Separation of Sister Chromatids
Establishment of Sister Chromatid Cohesion
Cohesin Loading onto Chromatin
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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