ENSG00000066923


Homo sapiens

Features
Gene ID: ENSG00000066923
  
Biological name :STAG3
  
Synonyms : Q9UJ98 / STAG3 / stromal antigen 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q22.1
Gene start: 100177563
Gene end: 100221488
  
Corresponding Affymetrix probe sets: 219753_at (Human Genome U133 Plus 2.0 Array)   219812_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400359
Ensembl peptide - ENSP00000397067
Ensembl peptide - ENSP00000407884
Ensembl peptide - ENSP00000484098
Ensembl peptide - ENSP00000477973
Ensembl peptide - ENSP00000409283
Ensembl peptide - ENSP00000319318
Ensembl peptide - ENSP00000377586
Ensembl peptide - ENSP00000393790
Ensembl peptide - ENSP00000395039
NCBI entrez gene - 10734     See in Manteia.
OMIM - 608489
RefSeq - XM_017011687
RefSeq - NM_001282716
RefSeq - NM_001282717
RefSeq - NM_001282718
RefSeq - NM_012447
RefSeq - XM_011515742
RefSeq - XM_017011683
RefSeq - XM_017011684
RefSeq - XM_017011685
RefSeq - XM_017011686
RefSeq Peptide - NP_001269647
RefSeq Peptide - NP_036579
RefSeq Peptide - NP_001269646
RefSeq Peptide - NP_001269645
swissprot - H0Y4S6
swissprot - H7C0H6
swissprot - Q9UJ98
swissprot - C9J3T3
swissprot - D6W5U7
swissprot - C9JYW5
swissprot - C9JTG4
Ensembl - ENSG00000066923
  
Related genetic diseases (OMIM): 615723 - Premature ovarian failure 8, 615723
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stag3ENSDARG00000104388Danio rerio
 Stag3ENSMUSG00000036928Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STAG2 / Q8N3U4 / stromal antigen 2ENSG0000010197248
STAG1 / Q8WVM7 / stromal antigen 1ENSG0000011800748


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR013721  STAG
 IPR016024  Armadillo-type fold
 IPR020839  Stromalin conservative domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0007129 synapsis IEA
 biological_processGO:0007130 synaptonemal complex assembly TAS
 biological_processGO:0034502 protein localization to chromosome IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0000794 condensed nuclear chromosome IEA
 cellular_componentGO:0000795 synaptonemal complex IEA
 cellular_componentGO:0000800 lateral element IEA
 cellular_componentGO:0000802 transverse filament IEA
 cellular_componentGO:0001673 male germ cell nucleus IEA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0030893 meiotic cohesin complex IEA
 cellular_componentGO:0034991 nuclear meiotic cohesin complex IEA
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
Meiotic synapsis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0000786 Primary amenorrhea 
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 HP:0000837 Elevated gonadotropins 
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 HP:0008209 Premature ovarian failure 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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