ENSMUSG00000037296


Mus musculus

Features
Gene ID: ENSMUSG00000037296
  
Biological name :Lsm1
  
Synonyms : Lsm1 / Q8VC85 / U6 snRNA-associated Sm-like protein LSm1
  
Possible biological names infered from orthology : LSM1 homolog, mRNA degradation associated / O15116
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A2
Gene start: 25785288
Gene end: 25803975
  
Corresponding Affymetrix probe sets: 10571048 (MoGene1.0st)   1423873_at (Mouse Genome 430 2.0 Array)   1441452_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041022
Ensembl peptide - ENSMUSP00000147832
Ensembl peptide - ENSMUSP00000147348
NCBI entrez gene - 67207     See in Manteia.
MGI - MGI:1914457
RefSeq - NM_026032
RefSeq Peptide - NP_080308
swissprot - A0A1B0GR26
swissprot - A0A1B0GS83
swissprot - Q544C9
swissprot - Q8VC85
Ensembl - ENSMUSG00000037296
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lsm1ENSDARG00000043177Danio rerio
 LSM1ENSGALG00000003245Gallus gallus
 LSM1ENSG00000175324Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001163  LSM domain, eukaryotic/archaea-type
 IPR010920  LSM domain superfamily
 IPR034104  Sm-like protein Lsm1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IBA
 biological_processGO:0000956 nuclear-transcribed mRNA catabolic process IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0071044 histone mRNA catabolic process IEA
 cellular_componentGO:0000932 P-body IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005845 mRNA cap binding complex IBA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:1990124 messenger ribonucleoprotein complex IEA
 cellular_componentGO:1990726 Lsm1-7-Pat1 complex IBA
 molecular_functionGO:0000339 RNA cap binding IBA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0036002 pre-mRNA binding IEA


Pathways (from Reactome)
Pathway description
mRNA decay by 5 to 3 exoribonuclease


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0010574 aorta dilation "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Lrrk1tm1b(KOMP)Wtsi/Lrrk1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Lrrk1tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr