ENSMUSG00000037313


Mus musculus

Features
Gene ID: ENSMUSG00000037313
  
Biological name :Tacc3
  
Synonyms : Tacc3 / transforming, acidic coiled-coil containing protein 3
  
Possible biological names infered from orthology : Q9Y6A5
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B2
Gene start: 33658128
Gene end: 33678995
  
Corresponding Affymetrix probe sets: 10521090 (MoGene1.0st)   1417450_a_at (Mouse Genome 430 2.0 Array)   1436872_at (Mouse Genome 430 2.0 Array)   1455834_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117407
Ensembl peptide - ENSMUSP00000119560
Ensembl peptide - ENSMUSP00000144567
Ensembl peptide - ENSMUSP00000074394
Ensembl peptide - ENSMUSP00000078491
Ensembl peptide - ENSMUSP00000110069
Ensembl peptide - ENSMUSP00000115481
NCBI entrez gene - 21335     See in Manteia.
MGI - MGI:1341163
RefSeq - XM_006503835
RefSeq - XM_006503832
RefSeq - XM_011240716
RefSeq - XM_011240715
RefSeq - NM_001040435
RefSeq - NM_001310541
RefSeq - XM_017320784
RefSeq Peptide - NP_001297470
RefSeq Peptide - NP_001035525
swissprot - Q99LH8
swissprot - Q6NV52
swissprot - D3Z1Y4
swissprot - A0A0J9YVA2
swissprot - F7AGT6
swissprot - F6TNB3
Ensembl - ENSMUSG00000037313
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tacc3ENSDARG00000005454Danio rerio
 TACC3ENSGALG00000015709Gallus gallus
 TACC3ENSG00000013810Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tacc2 / Q9JJG0 / Mus musculus transforming, acidic coiled-coil containing protein 2 (Tacc2), transcript variant 4, mRNA. / O95359* / transforming acidic coiled-coil containing protein 2*ENSMUSG0000003085230
Tacc1 / Q6Y685 / Transforming acidic coiled-coil-containing protein 1 / O75410*ENSMUSG0000006595420


Protein motifs (from Interpro)
Interpro ID Name
 IPR007707  Transforming acidic coiled-coil-containing protein, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
No match


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000074 abnormal neurocranium morphology "malformed bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0000755 hindlimb paralysis "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Tacc3tm1.1Tno/Tacc3tm1.2Tno,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Tacc3tm1.1Tno/Tacc3+,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Tacc3tm1.1Tno/Tacc3tm1.1Tno
Genetic Background: involves: C57BL/6

 MP:0003050 abnormal sacral vertebrae morphology "malformation of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003794 delayed somite formation "late onset of the induction and/or differentiation of the somites" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99723]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Tacc3tm1.2Tno/Tacc3tm1.2Tno
Genetic Background: involves: C57BL/6

Allelic Composition: Tacc3tm1Tno/Tacc3tm1.2Tno
Genetic Background: involves: C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Tacc3tm1.1Tno/Tacc3tm1.2Tno
Genetic Background: involves: C57BL/6

 MP:0004599 abnormal vertebral arch morphology "any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004621 lumbar vertebral fusion "the union of one or more lumbar vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004653 absent caudal vertebrae "absence of all of the bony segments of the coccyx or tail; there are usually 27-30 present in rodents and only 3-5 fused vertebrae in human" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0010268 decreased lymphoma incidence "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+,Tacc3tm1.1Tno/Tacc3tm1.2Tno,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Tacc3tm1.2Tno/Tacc3tm1.2Tno
Genetic Background: involves: C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Tacc3tm1Tno/Tacc3tm1.2Tno
Genetic Background: involves: C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Syt1tm1Sud/Syt1tm1Sud,Tg(Thy1-Syt1/ECFP)1Sud/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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