ENSMUSG00000037426


Mus musculus

Features
Gene ID: ENSMUSG00000037426
  
Biological name :Depdc5
  
Synonyms : Depdc5 / GATOR complex protein DEPDC5 / P61460
  
Possible biological names infered from orthology : DEP domain containing 5 / O75140 / Z82190.2
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: B1
Gene start: 32863701
Gene end: 32994236
  
Corresponding Affymetrix probe sets: 10520982 (MoGene1.0st)   1435535_at (Mouse Genome 430 2.0 Array)   1442410_at (Mouse Genome 430 2.0 Array)   1444996_at (Mouse Genome 430 2.0 Array)   1457500_at (Mouse Genome 430 2.0 Array)   1458615_at (Mouse Genome 430 2.0 Array)   1458843_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118681
Ensembl peptide - ENSMUSP00000116704
Ensembl peptide - ENSMUSP00000120120
Ensembl peptide - ENSMUSP00000144461
Ensembl peptide - ENSMUSP00000144004
Ensembl peptide - ENSMUSP00000143228
Ensembl peptide - ENSMUSP00000122461
Ensembl peptide - ENSMUSP00000122173
Ensembl peptide - ENSMUSP00000121089
Ensembl peptide - ENSMUSP00000052807
Ensembl peptide - ENSMUSP00000085207
Ensembl peptide - ENSMUSP00000112906
Ensembl peptide - ENSMUSP00000113862
Ensembl peptide - ENSMUSP00000113980
NCBI entrez gene - 277854     See in Manteia.
MGI - MGI:2141101
RefSeq - XM_017320910
RefSeq - NM_001025426
RefSeq - NM_001170567
RefSeq - NM_177786
RefSeq - XM_006503978
RefSeq - XM_006503979
RefSeq - XM_006503980
RefSeq - XM_006503981
RefSeq - XM_006503982
RefSeq - XM_006503983
RefSeq - XM_006503984
RefSeq - XM_006503985
RefSeq - XM_006503986
RefSeq - XM_006503987
RefSeq - XM_006503988
RefSeq - XM_006503989
RefSeq - XM_017320908
RefSeq Peptide - NP_001020597
RefSeq Peptide - NP_001164038
RefSeq Peptide - NP_808454
swissprot - D3Z5Y4
swissprot - D3Z419
swissprot - A0A0J9YV31
swissprot - F6TK47
swissprot - F6X8H7
swissprot - E9QAT3
swissprot - A0A0J9YU49
swissprot - P61460
swissprot - Q6GQV2
swissprot - A0A0G2JFM3
swissprot - F6XIK0
swissprot - E9PWF2
swissprot - D3Z7M7
Ensembl - ENSMUSG00000037426
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 depdc5ENSDARG00000078105Danio rerio
 ENSGALG00000006766Gallus gallus
 DEPDC5ENSG00000100150Homo sapiens
 Z82190.2ENSG00000285404Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000591  DEP domain
 IPR027244  Vacuolar membrane-associated protein Iml1
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010506 regulation of autophagy IBA
 biological_processGO:0032007 negative regulation of TOR signaling ISO
 biological_processGO:0034198 cellular response to amino acid starvation IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:1904262 negative regulation of TORC1 signaling ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:1990130 GATOR1 complex IBA
 molecular_functionGO:0005096 GTPase activator activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000434 megacephaly "an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

Allelic Composition: Depdc5tm1c(EUCOMM)Hmgu/Depdc5+,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: C57BL/6N * CBA

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0002826 tonic seizures "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0002906 susceptibility to pharmacologically induced seizures "inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:69504]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0005238 increased brain size "larger than the normal physical proportions of the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57958]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

 MP:0005603 neuron hypertrophy "increased mass of any of the structural and functional units of the nervous system, which consist of the nerve cell body, the dendrites, and the axon" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Psmb10tm1Mgro/Psmb10Tub6
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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