ENSMUSG00000037608


Mus musculus

Features
Gene ID: ENSMUSG00000037608
  
Biological name :Bclaf1
  
Synonyms : Bcl-2-associated transcription factor 1 / Bclaf1 / Q8K019
  
Possible biological names infered from orthology : Q9NYF8
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A3
Gene start: 20312469
Gene end: 20344613
  
Corresponding Affymetrix probe sets: 10361979 (MoGene1.0st)   1428844_a_at (Mouse Genome 430 2.0 Array)   1428845_at (Mouse Genome 430 2.0 Array)   1430581_at (Mouse Genome 430 2.0 Array)   1436023_at (Mouse Genome 430 2.0 Array)   1438089_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140608
Ensembl peptide - ENSMUSP00000140428
Ensembl peptide - ENSMUSP00000140623
Ensembl peptide - ENSMUSP00000140702
Ensembl peptide - ENSMUSP00000043583
Ensembl peptide - ENSMUSP00000090349
Ensembl peptide - ENSMUSP00000140101
NCBI entrez gene - 72567     See in Manteia.
MGI - MGI:1917580
RefSeq - XM_011243207
RefSeq - NM_001025392
RefSeq - NM_001025393
RefSeq - NM_153787
RefSeq - XM_006512865
RefSeq Peptide - NP_001020564
RefSeq Peptide - NP_001020563
RefSeq Peptide - NP_722482
swissprot - F8WI22
swissprot - A0A087WRF8
swissprot - A0A087WRN1
swissprot - A0A087WQA0
swissprot - Q8K019
Ensembl - ENSMUSG00000037608
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BCLAF1ENSGALG00000013935Gallus gallus
 BCLAF1ENSG00000029363Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q569Z6 / Thrap3 / thyroid hormone receptor associated protein 3 / Q9Y2W1*ENSMUSG0000004396241
A2AG58 / Bclaf3 / Bclaf1 and Thrap3 family member 3 / A2AJT9*ENSMUSG0000004415015


Protein motifs (from Interpro)
Interpro ID Name
 IPR026668  Bcl-2-associated transcription factor 1
 IPR029199  THRAP3/BCLAF1 family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043620 regulation of DNA-templated transcription in response to stress ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2000144 positive regulation of DNA-templated transcription, initiation ISO
 biological_processGO:2001022 positive regulation of response to DNA damage stimulus IEA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Cck-cre)CKres/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Cck-cre)CKres/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Cck-cre)CKres/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Bbs7tm1b(EUCOMM)Wtsi/Bbs7tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Bbs7tm1b(EUCOMM)Wtsi/J

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Cck-cre)CKres/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Cck-cre)CKres/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Bclaf1tm1Raz/Bclaf1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Cck-cre)CKres/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Cck-cre)CKres/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Cck-cre)CKres/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Bbs7tm1b(EUCOMM)Wtsi/Bbs7tm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Bbs7tm1b(EUCOMM)Wtsi/J

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Cck-cre)CKres/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0011145 abnormal mesenchymal cell differentiation involved in lung development "abnormal or arrest of differentiation of the mesenchymal cell population in the developing lung" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Tg(Cck-cre)CKres/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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