ENSMUSG00000037625


Mus musculus

Features
Gene ID: ENSMUSG00000037625
  
Biological name :Cldn11
  
Synonyms : Claudin-11 / Cldn11 / Q60771
  
Possible biological names infered from orthology : AC026316.5 / O75508
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 31149920
Gene end: 31164324
  
Corresponding Affymetrix probe sets: 10491313 (MoGene1.0st)   1416003_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042181
NCBI entrez gene - 18417     See in Manteia.
MGI - MGI:106925
RefSeq - NM_008770
RefSeq Peptide - NP_032796
swissprot - Q60771
Ensembl - ENSMUSG00000037625
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cldn11aENSDARG00000020031Danio rerio
 cldn11bENSDARG00000030723Danio rerio
 ENSGALG00000009355Gallus gallus
 AC026316.5ENSG00000285218Homo sapiens
 CLDN11ENSG00000013297Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003555  Claudin-11
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR006187  Claudin
 IPR017974  Claudin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008366 axon ensheathment IMP
 biological_processGO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005923 bicellular tight junction ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045178 basal part of cell IDA
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000048 abnormal stria vascularis "anomalous structure of the layer of highly vascularized pigmented granular cells on the outer wall of the cochlear duct" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cldn11tm1Sts/Cldn11tm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001515 abnormal grip strength "altered ability to grasp and hold objects, usually measured as time spent hanging from an object or wire" [J:80661]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cldn11tm1Sts/Cldn11tm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001967 deafness "inability to hear" [J:57651]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004404 cochlear outer hair cell degeneration "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004411 decreased endocochlear potential "reduction of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cldn11tm1Sts/Cldn11tm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004464 absent strial basal cell tight junctions "absence of tight junctions from the basal cell layer of stria vascularis, resulting in destruction of the paracellular barrier between basal cells; loss of basal cell tight junctions renders the intrastrial space open to perilymph and abolishes its electrical isolation" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cldn11tm1Sts/Cldn11tm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010748 abnormal visual evoked potential "anomaly in the electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; may be used to evaluate optic nerve damage or visual perception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Cldn11tm1Sts/Cldn11tm1Sts
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0020355 abnormal Sertoli cell barrier morphology "any structural anomaly of the physical barrier found between adjacent Sertoli cells within the seminiferous tubules; the sertoli cell barrier consists of several types of cellular junctions including tight junctions, gap junctions and adhesion junctions, and divides the seminiferous tubules into the basal and apical (adluminal) compartments" [PMID:24713828 http://www.ajandrology.com/article.asp?issn=1008-682X;year=2014;volume=16;issue=4;spage=572;epage=580;aulast=Jiang]
Show

Allelic Composition: Ugt8atm1Pop/Ugt8a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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