ENSMUSG00000037953


Mus musculus

Features
Gene ID: ENSMUSG00000037953
  
Biological name :A4gnt
  
Synonyms : A4gnt / alpha-1,4-N-acetylglucosaminyltransferase / Q14BT6
  
Possible biological names infered from orthology : Q9UNA3
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.3
Gene start: 99612502
Gene end: 99622367
  
Corresponding Affymetrix probe sets: 10588132 (MoGene1.0st)   1458930_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045629
NCBI entrez gene - 333424     See in Manteia.
MGI - MGI:2143261
RefSeq - XM_006511246
RefSeq - NM_001077424
RefSeq - XM_006511244
RefSeq Peptide - NP_001070892
swissprot - Q14BT6
Ensembl - ENSMUSG00000037953
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A4GNTENSGALG00000006600Gallus gallus
 A4GNTENSG00000118017Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A4galt / Q67BJ4 / alpha 1,4-galactosyltransferase / Q9NPC4* / alpha 1,4-galactosyltransferase (P blood group)*ENSMUSG0000004787831


Protein motifs (from Interpro)
Interpro ID Name
 IPR007577  Glycosyltransferase, DXD sugar-binding motif
 IPR007652  Alpha 1,4-glycosyltransferase domain
 IPR029044  Nucleotide-diphospho-sugar transferases


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006493 protein O-linked glycosylation IMP
 biological_processGO:0009101 glycoprotein biosynthetic process IEA
 biological_processGO:0050680 negative regulation of epithelial cell proliferation IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008375 acetylglucosaminyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA


Pathways (from Reactome)
Pathway description
O-linked glycosylation of mucins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: CasrBCH013/CasrBCH013
Genetic Background: C3HeB/FeJ-CasrBCH013

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: CasrBCH013/CasrBCH013
Genetic Background: C3HeB/FeJ-CasrBCH013

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: CasrBCH013/CasrBCH013
Genetic Background: C3HeB/FeJ-CasrBCH013

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: CasrBCH013/CasrBCH013
Genetic Background: C3HeB/FeJ-CasrBCH013

 MP:0005493 stomach epithelial hyperplasia 
Show

Allelic Composition: CasrBCH013/CasrBCH013
Genetic Background: C3HeB/FeJ-CasrBCH013

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: CasrBCH013/CasrBCH013
Genetic Background: C3HeB/FeJ-CasrBCH013

 MP:0008010 gastric adenocarcinoma "malignant neoplasm of epithelial cells in the stomach" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: CasrBCH013/CasrBCH013
Genetic Background: C3HeB/FeJ-CasrBCH013

 MP:0010792 abnormal stomach mucosa morphology "any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: CasrBCH013/CasrBCH013
Genetic Background: C3HeB/FeJ-CasrBCH013

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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