ENSMUSG00000038180


Mus musculus

Features
Gene ID: ENSMUSG00000038180
  
Biological name :Spag4
  
Synonyms : Q9JJF2 / Spag4 / Sperm-associated antigen 4 protein
  
Possible biological names infered from orthology : Q9NPE6 / sperm associated antigen 4
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H1
Gene start: 156065175
Gene end: 156070617
  
Corresponding Affymetrix probe sets: 10477791 (MoGene1.0st)   1452407_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036484
Ensembl peptide - ENSMUSP00000118715
Ensembl peptide - ENSMUSP00000120079
Ensembl peptide - ENSMUSP00000121781
NCBI entrez gene - 245865     See in Manteia.
MGI - MGI:2444120
RefSeq - XM_006499540
RefSeq - NM_139151
RefSeq Peptide - NP_631890
swissprot - F6S430
swissprot - B7ZCP3
swissprot - Q9JJF2
swissprot - F6XNA5
Ensembl - ENSMUSG00000038180
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-92f12.2ENSDARG00000086490Danio rerio
 ENSGALG00000046588Gallus gallus
 ENSGALG00000046657Gallus gallus
 ENSGALG00000045972Gallus gallus
 ENSGALG00000044446Gallus gallus
 ENSGALG00000046307Gallus gallus
 ENSGALG00000040952Gallus gallus
 ENSGALG00000025763Gallus gallus
 ENSGALG00000045978Gallus gallus
 ENSGALG00000046242Gallus gallus
 ENSGALG00000046634Gallus gallus
 SPAG4ENSG00000061656Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sun5 / SUN domain-containing protein 5 isoform 1 / Q8TC36* / Sad1 and UNC84 domain containing 5*ENSMUSG0000002748027
Sun1 / Q9D666 / Sad1 and UNC84 domain containing 1 / O94901*ENSMUSG0000003681727
Sun2 / Q8BJS4 / SUN domain-containing protein 2 / Q9UH99* / Sad1 and UNC84 domain containing 2*ENSMUSG0000004252424
Sun3 / Q5SS91 / SUN domain-containing protein 3 / Q8TAQ9* / Sad1 and UNC84 domain containing 3*ENSMUSG0000004098521


Protein motifs (from Interpro)
Interpro ID Name
 IPR008979  Galactose-binding-like domain superfamily
 IPR012919  SUN domain
 IPR027776  Sperm-associated antigen 4 protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006998 nuclear envelope organization IBA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0090286 cytoskeletal anchoring at nuclear membrane IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0043495 protein membrane anchor IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6N

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6N

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6N

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6N

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scribtm1b(NCOM)Mfgc/Scribtm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Scribtm1a(NCOM)Mfgc/Tcp

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6N

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6N

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6N

 MP:0009232 abnormal sperm nucleus morphology "any structural abnormality of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6N

 MP:0009238 coiled sperm flagellum "abnormal twisting of the sperm flagellum into coils or spirals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6N

 MP:0009376 abnormal manchette morphology "any structural abnormality of the conic array of microtubules that invests the posterior nucleus of a spermatid, and is believed to play a role in definitive posterior head-shaping events during spermiogenesis" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Commd9tm1c(KOMP)Wtsi/Commd9tm1c(KOMP)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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