ENSMUSG00000042524


Mus musculus

Features
Gene ID: ENSMUSG00000042524
  
Biological name :Sun2
  
Synonyms : Q8BJS4 / Sun2 / SUN domain-containing protein 2
  
Possible biological names infered from orthology : Q9UH99 / Sad1 and UNC84 domain containing 2
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 79724070
Gene end: 79742536
  
Corresponding Affymetrix probe sets: 10430596 (MoGene1.0st)   1433832_at (Mouse Genome 430 2.0 Array)   1439238_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000098006
Ensembl peptide - ENSMUSP00000124515
Ensembl peptide - ENSMUSP00000124504
Ensembl peptide - ENSMUSP00000124495
Ensembl peptide - ENSMUSP00000047864
Ensembl peptide - ENSMUSP00000086724
NCBI entrez gene - 223697     See in Manteia.
MGI - MGI:2443011
RefSeq - XM_006520811
RefSeq - NM_001205345
RefSeq - NM_001205346
RefSeq - NM_194342
RefSeq Peptide - NP_001192275
RefSeq Peptide - NP_001192274
RefSeq Peptide - NP_919323
swissprot - Q8BJS4
swissprot - E0CY32
swissprot - E0CY44
swissprot - E0CY39
Ensembl - ENSMUSG00000042524
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-92f12.2ENSDARG00000086490Danio rerio
 SUN2ENSGALG00000028230Gallus gallus
 SUN2ENSG00000100242Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sun1 / Q9D666 / Sad1 and UNC84 domain containing 1 / O94901*ENSMUSG0000003681731
Sun3 / Q5SS91 / SUN domain-containing protein 3 / Q8TAQ9* / Sad1 and UNC84 domain containing 3*ENSMUSG0000004098515
Spag4 / Q9JJF2 / Sperm-associated antigen 4 protein / Q9NPE6* / sperm associated antigen 4*ENSMUSG0000003818015
Sun5 / SUN domain-containing protein 5 isoform 1 / Q8TC36* / Sad1 and UNC84 domain containing 5*ENSMUSG0000002748013


Protein motifs (from Interpro)
Interpro ID Name
 IPR008979  Galactose-binding-like domain superfamily
 IPR012919  SUN domain
 IPR030272  SUN domain-containing protein 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006998 nuclear envelope organization IEA
 biological_processGO:0021817 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration IMP
 biological_processGO:0030335 positive regulation of cell migration IMP
 biological_processGO:0031022 nuclear migration along microfilament IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0051642 centrosome localization IMP
 biological_processGO:0090286 cytoskeletal anchoring at nuclear membrane IEA
 biological_processGO:0090292 nuclear matrix anchoring at nuclear membrane IEA
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0000794 condensed nuclear chromosome IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005639 integral component of nuclear inner membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0034993 meiotic nuclear membrane microtubule tethering complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005521 lamin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043495 protein membrane anchor IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj,Sun2tm1.1Cyh/Sun2+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj,Sun2tm1.1Cyh/Sun2+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj,Sun2tm1.1Cyh/Sun2+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

Allelic Composition: Sun1tm1.1Ktj/Sun1+,Sun2tm1.1Cyh/Sun2tm1.1Cyh
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj,Sun2tm1.1Cyh/Sun2+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj,Sun2tm1.1Cyh/Sun2+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj,Sun2tm1.1Cyh/Sun2+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj,Sun2tm1.1Cyh/Sun2+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj,Sun2tm1.1Cyh/Sun2+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
Show

Allelic Composition: Sun1tm1Mhan/Sun1tm1Mhan,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Baz1btm1Ska/Baz1b+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Sun1tm1Mhan/Sun1tm1Mhan,Sun2tm1Mhan/Sun2+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Sun1tm1Mhan/Sun1+,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Baz1btm1Ska/Baz1b+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004996 abnormal CNS synapse formation "any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj,Sun2tm1.1Cyh/Sun2+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj,Sun2tm1.1Cyh/Sun2+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0009267 abnormal cerebellum fissure morphology "any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj,Sun2tm1.1Cyh/Sun2+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sun1tm1Mhan/Sun1tm1Mhan,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj,Sun2tm1.1Cyh/Sun2+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0010008 abnormal Purkinje cell migration "defective or impaired movement of immature Purkinje cells from the ventricular zone of the fourth ventricle to the forming Purkinje cell layer during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj,Sun2tm1.1Cyh/Sun2+
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Sun1tm1Mhan/Sun1tm1Mhan,Sun2tm1Mhan/Sun2tm1Mhan
Genetic Background: involves: 129S6/SvEvTac

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Sun1tm1.1Ktj/Sun1tm1.1Ktj
Genetic Background: involves: 129/Sv * C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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