ENSMUSG00000038208


Mus musculus

Features
Gene ID: ENSMUSG00000038208
  
Biological name :Pgap3
  
Synonyms : A2A559 / Pgap3 / Post-GPI attachment to proteins factor 3
  
Possible biological names infered from orthology : post-GPI attachment to proteins 3 / Q96FM1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 98388677
Gene end: 98400490
  
Corresponding Affymetrix probe sets: 10390622 (MoGene1.0st)   1435037_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119668
Ensembl peptide - ENSMUSP00000088337
NCBI entrez gene - 320655     See in Manteia.
MGI - MGI:2444461
RefSeq - NM_001033537
RefSeq - XM_006533549
RefSeq - XM_006533550
RefSeq Peptide - NP_001028709
swissprot - A2A559
Ensembl - ENSMUSG00000038208
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pgap3ENSDARG00000057531Danio rerio
 PGAP3ENSGALG00000022030Gallus gallus
 PGAP3ENSG00000161395Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007217  Per1-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006505 GPI anchor metabolic process ISO
 biological_processGO:0006506 GPI anchor biosynthetic process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031227 intrinsic component of endoplasmic reticulum membrane ISO
 molecular_functionGO:0016788 hydrolase activity, acting on ester bonds ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Hmgcltm2Gam/Hmgcltm2Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hmgcltm2Gam Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hmgcltm2Gam/Hmgcltm2Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hmgcltm2Gam Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Hmgcltm2Gam/Hmgcltm2Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hmgcltm2Gam Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hmgcltm2Gam/Hmgcltm2Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hmgcltm2Gam Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vangl1tm1.1Nat/Vangl1tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmgcltm2Gam/Hmgcltm2Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hmgcltm2Gam Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vangl1tm1.1Nat/Vangl1tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vangl1tm1.1Nat/Vangl1tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgcltm2Gam/Hmgcltm2Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hmgcltm2Gam Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Vangl1tm1.1Nat/Vangl1tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hmgcltm2Gam/Hmgcltm2Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hmgcltm2Gam Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hmgcltm2Gam/Hmgcltm2Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hmgcltm2Gam Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hmgcltm2Gam/Hmgcltm2Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hmgcltm2Gam Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgcltm2Gam/Hmgcltm2Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hmgcltm2Gam Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vangl1tm1.1Nat/Vangl1tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Vangl1tm1.1Nat/Vangl1tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hmgcltm2Gam/Hmgcltm2Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hmgcltm2Gam Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
Show

Allelic Composition: Vangl1tm1.1Nat/Vangl1tm1.1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011496 abnormal head size "anomaly in the average size of the portion of the body containing the brain and organs of sight, hearing, taste, and smell" [MGI:csmith]
Show

Allelic Composition: Hmgcltm2Gam/Hmgcltm2Gam,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hmgcltm2Gam Speer6-ps1Tg(Alb-cre)21Mgn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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