ENSMUSG00000038242


Mus musculus

Features
Gene ID: ENSMUSG00000038242
  
Biological name :Aox4
  
Synonyms : Aldehyde oxidase 4 / Aox4 / Q3TYQ9
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C1.3
Gene start: 58210397
Gene end: 58268597
  
Corresponding Affymetrix probe sets: 10346448 (MoGene1.0st)   1419215_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048929
NCBI entrez gene - 71872     See in Manteia.
MGI - MGI:1919122
RefSeq - NM_023631
RefSeq - XM_006496287
RefSeq Peptide - NP_076120
swissprot - Q3TYQ9
Ensembl - ENSMUSG00000038242
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aox6ENSDARG00000020054Danio rerio
 AOX2ENSGALG00000020876Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aox3 / G3X982 / Aldehyde oxidase 3 ENSMUSG0000006429464
Aox2 / Q5SGK3 / Aldehyde oxidase 2 ENSMUSG0000007955463
Aox1 / aldehyde oxidase 1 / Q06278*ENSMUSG0000006355858
Xdh / Q00519 / xanthine dehydrogenase / P47989*ENSMUSG0000002406648


Protein motifs (from Interpro)
Interpro ID Name
 IPR000674  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
 IPR001041  2Fe-2S ferredoxin-type iron-sulfur binding domain
 IPR002346  Molybdopterin dehydrogenase, FAD-binding
 IPR002888  [2Fe-2S]-binding
 IPR005107  CO dehydrogenase flavoprotein, C-terminal
 IPR006058  2Fe-2S ferredoxin, iron-sulphur binding site
 IPR008274  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
 IPR012675  Beta-grasp domain superfamily
 IPR014313  Aldehyde oxidase
 IPR016166  FAD-binding, type 2
 IPR016167  FAD-binding, type 2, subdomain 1
 IPR016208  Aldehyde oxidase/xanthine dehydrogenase
 IPR036010  2Fe-2S ferredoxin-like superfamily
 IPR036318  FAD-binding, type 2-like superfamily
 IPR036683  CO dehydrogenase flavoprotein, C-terminal domain superfamily
 IPR036856  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
 IPR036884  [2Fe-2S]-binding domain superfamily
 IPR037165  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009115 xanthine catabolic process IBA
 biological_processGO:0017144 drug metabolic process ISS
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0055114 oxidation-reduction process ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004031 aldehyde oxidase activity ISA
 molecular_functionGO:0004854 xanthine dehydrogenase activity IBA
 molecular_functionGO:0005506 iron ion binding ISS
 molecular_functionGO:0009055 electron transfer activity ISA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016614 oxidoreductase activity, acting on CH-OH group of donors IEA
 molecular_functionGO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors IBA
 molecular_functionGO:0030151 molybdenum ion binding ISA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043546 molybdopterin cofactor binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050250 retinal oxidase activity ISS
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IBA
 molecular_functionGO:0051287 NAD binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051537 2 iron, 2 sulfur cluster binding ISS
 molecular_functionGO:0102797 geranial:oxygen oxidoreductase activity IEA
 molecular_functionGO:0102798 heptaldehyde:oxygen oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
Show

Allelic Composition: KitlSl-J/Kitl+
Genetic Background: involves: 129

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: KitlSl-J/Kitl+
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr