ENSMUSG00000024066


Mus musculus

Features
Gene ID: ENSMUSG00000024066
  
Biological name :Xdh
  
Synonyms : Q00519 / xanthine dehydrogenase / Xdh
  
Possible biological names infered from orthology : P47989
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E2
Gene start: 73883908
Gene end: 73950182
  
Corresponding Affymetrix probe sets: 10452815 (MoGene1.0st)   1424609_a_at (Mouse Genome 430 2.0 Array)   1451006_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024866
NCBI entrez gene - 22436     See in Manteia.
MGI - MGI:98973
RefSeq - NM_011723
RefSeq Peptide - NP_035853
swissprot - Q00519
Ensembl - ENSMUSG00000024066
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xdhENSDARG00000055240Danio rerio
 XDHENSGALG00000008701Gallus gallus
 XDHENSG00000158125Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aox2 / Q5SGK3 / Aldehyde oxidase 2 ENSMUSG0000007955451
Aox3 / G3X982 / Aldehyde oxidase 3 ENSMUSG0000006429450
Aox1 / aldehyde oxidase 1 / Q06278*ENSMUSG0000006355849
Aox4 / Q3TYQ9 / Aldehyde oxidase 4 ENSMUSG0000003824248


Protein motifs (from Interpro)
Interpro ID Name
 IPR000674  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
 IPR001041  2Fe-2S ferredoxin-type iron-sulfur binding domain
 IPR002346  Molybdopterin dehydrogenase, FAD-binding
 IPR002888  [2Fe-2S]-binding
 IPR005107  CO dehydrogenase flavoprotein, C-terminal
 IPR006058  2Fe-2S ferredoxin, iron-sulphur binding site
 IPR008274  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
 IPR012675  Beta-grasp domain superfamily
 IPR014307  Xanthine dehydrogenase, small subunit
 IPR014309  Xanthine dehydrogenase, molybdopterin binding subunit
 IPR016166  FAD-binding, type 2
 IPR016167  FAD-binding, type 2, subdomain 1
 IPR016208  Aldehyde oxidase/xanthine dehydrogenase
 IPR022407  Oxidoreductase, molybdopterin binding site
 IPR036010  2Fe-2S ferredoxin-like superfamily
 IPR036318  FAD-binding, type 2-like superfamily
 IPR036683  CO dehydrogenase flavoprotein, C-terminal domain superfamily
 IPR036856  Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily
 IPR036884  [2Fe-2S]-binding domain superfamily
 IPR037165  Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IEA
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007595 lactation IMP
 biological_processGO:0009115 xanthine catabolic process IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0030856 regulation of epithelial cell differentiation IMP
 biological_processGO:0045602 negative regulation of endothelial cell differentiation IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0055114 oxidation-reduction process IDA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:1900747 negative regulation of vascular endothelial growth factor signaling pathway IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2001213 negative regulation of vasculogenesis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0016529 sarcoplasmic reticulum IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004854 xanthine dehydrogenase activity ISO
 molecular_functionGO:0004855 xanthine oxidase activity ISO
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009055 electron transfer activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IDA
 molecular_functionGO:0016614 oxidoreductase activity, acting on CH-OH group of donors IEA
 molecular_functionGO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors IBA
 molecular_functionGO:0030151 molybdenum ion binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043546 molybdopterin cofactor binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050660 flavin adenine dinucleotide binding IBA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051537 2 iron, 2 sulfur cluster binding ISO


Pathways (from Reactome)
Pathway description
Purine catabolism
Butyrophilin (BTN) family interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc1tm1Rpe/Xrcc1tm1Rpe
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc1tm1Rpe/Xrcc1tm1Rpe
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc1tm1Rpe/Xrcc1tm1Rpe
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc1tm1Rpe/Xrcc1tm1Rpe
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc1tm1Rpe/Xrcc1tm1Rpe
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rargtm3.1Ipc/Rargtm3.1Ipc
Genetic Background: involves: C57BL/6 * SJL

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0003432 increased activity of parathyroid "increased function of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc1tm1Rpe/Xrcc1tm1Rpe
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc1tm1Rpe/Xrcc1tm1Rpe
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc1tm1Rpe/Xrcc1tm1Rpe
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0008806 increased circulating amylase level "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008822 decreased blood uric acid level "reduced concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009645 crystalluria "excretion of crystalline material in the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Xrcc1tm1Rpe/Xrcc1tm1Rpe
Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0011405 tubulointerstitial nephritis "diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease" [MGI:anna]
Show

Allelic Composition: Xdhtm1Fink/Xdhtm1Fink
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024066 Xdh / Q00519 / xanthine dehydrogenase / P47989*  / complex
 ENSMUSG00000000706 Btn1a1 / Q62556 / Butyrophilin subfamily 1 member A1 / Q13410*  / reaction / complex






 

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