ENSMUSG00000000706


Mus musculus

Features
Gene ID: ENSMUSG00000000706
  
Biological name :Btn1a1
  
Synonyms : Btn1a1 / Butyrophilin subfamily 1 member A1 / Q62556
  
Possible biological names infered from orthology : Q13410
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.1
Gene start: 23456992
Gene end: 23465901
  
Corresponding Affymetrix probe sets: 10408175 (MoGene1.0st)   1419175_a_at (Mouse Genome 430 2.0 Array)   1425754_a_at (Mouse Genome 430 2.0 Array)   1451824_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041013
Ensembl peptide - ENSMUSP00000106064
NCBI entrez gene - 12231     See in Manteia.
MGI - MGI:103118
RefSeq - XM_006516535
RefSeq - NM_013483
RefSeq Peptide - NP_038511
swissprot - Q3UQC0
swissprot - Q62556
swissprot - Q921X1
Ensembl - ENSMUSG00000000706
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BTN1A1ENSGALG00000000589Gallus gallus
 BTN1A1ENSG00000124557Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A4QPC6 / Btn2a2 / Butyrophilin subfamily 2 member A2 / BTN2A1* / Q7KYR7* / Q8WVV5* / butyrophilin subfamily 2 member A1*ENSMUSG0000005321644
Ermap / erythroblast membrane associated protein (Scianna blood group) / Q96PL5*ENSMUSG0000002864436
Btnl4 / butyrophilin-like 4ENSMUSG0000005843536
Btnl6 / butyrophilin-like 6ENSMUSG0000009261835
Btnl9 / Q8BJE2 / Butyrophilin-like protein 9 / Q6UXG8* / butyrophilin like 9*ENSMUSG0000004028335
Btnl1 / Q7TST0 / Butyrophilin-like protein 1 ENSMUSG0000006263830
Btnl2 / O70355 / Butyrophilin-like protein 2 / Q9UIR0* / butyrophilin like 2*ENSMUSG0000002434023
Skint5 / selection and upkeep of intraepithelial T-cells protein 5 isoform 1 ENSMUSG0000007859822
A7XUZ6 / Skint6 / Selection and upkeep of intraepithelial T-cells protein 6 ENSMUSG0000008719421
A7TZF0 / Skint3 / Selection and upkeep of intraepithelial T-cells protein 3 ENSMUSG0000007086819
A7XUX6 / Skint2 / selection and upkeep of intraepithelial T cells 2ENSMUSG0000003435919
A7TZF3 / Skint4 / Mus musculus selection and upkeep of intraepithelial T cells 4 (Skint4), transcript variant 2, mRNA.ENSMUSG0000005596019
A7TZE6 / Skint1 / Selection and upkeep of intraepithelial T-cells protein 1 ENSMUSG0000008977318
Btnl10 / Q9JK39 / Butyrophilin-like protein 10 ENSMUSG0000002049017
A7XV04 / Skint7 / Selection and upkeep of intraepithelial T-cells protein 7 ENSMUSG0000004921416
A7XV07 / Skint8 / Selection and upkeep of intraepithelial T-cells protein 8 ENSMUSG0000007859916


Protein motifs (from Interpro)
Interpro ID Name
 IPR001870  B30.2/SPRY domain
 IPR003599  Immunoglobulin subtype
 IPR003877  SPRY domain
 IPR003879  Butyrophylin-like, SPRY domain
 IPR006574  SPRY-associated
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013162  CD80-like, immunoglobulin C2-set
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0031324 negative regulation of cellular metabolic process IDA
 biological_processGO:0046007 negative regulation of activated T cell proliferation IDA
 biological_processGO:0050710 negative regulation of cytokine secretion IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Butyrophilin (BTN) family interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
Show

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Hprttm1(Ggt1-Agtr1)Cof/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
Show

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Hprttm1(Ggt1-Agtr1)Cof/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Hprttm1(Ggt1-Agtr1)Cof/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Btn1a1tm2Ihm/Btn1a1tm2Ihm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039457 Ppl / periplakin / O60437*  / reaction / complex
 ENSMUSG00000024066 Xdh / Q00519 / xanthine dehydrogenase / P47989*  / reaction / complex






 

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