Manteia - Molecule gene

ENSMUSG00000038366

Mus musculus

Features

Gene ID:	ENSMUSG00000038366

Biological name :	Lasp1

Synonyms :	Lasp1 / LIM and SH3 domain protein 1 / Q61792

Possible biological names infered from orthology :	LIM and SH3 protein 1 / Q14847

Species:	Mus musculus

Chr. number:	11
Strand:	1
Band:	D
Gene start:	97799000
Gene end:	97838764

Corresponding Affymetrix probe sets:	10380823 (MoGene1.0st) 1438633_x_at (Mouse Genome 430 2.0 Array) 1438634_x_at (Mouse Genome 430 2.0 Array) 1439264_x_at (Mouse Genome 430 2.0 Array) 1448207_at (Mouse Genome 430 2.0 Array) 1455470_x_at (Mouse Genome 430 2.0 Array) 1456309_x_at (Mouse Genome 430 2.0 Array) 1456469_x_at (Mouse Genome 430 2.0 Array) 1456578_x_at (Mouse Genome 430 2.0 Array) 1460173_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000042123 Ensembl peptide - ENSMUSP00000127792 Ensembl peptide - ENSMUSP00000123165 Ensembl peptide - ENSMUSP00000123050 Ensembl peptide - ENSMUSP00000121907 Ensembl peptide - ENSMUSP00000120645 Ensembl peptide - ENSMUSP00000120458 Ensembl peptide - ENSMUSP00000119797 Ensembl peptide - ENSMUSP00000119538 Ensembl peptide - ENSMUSP00000116102 Ensembl peptide - ENSMUSP00000115308 Ensembl peptide - ENSMUSP00000114407 Ensembl peptide - ENSMUSP00000114306 NCBI entrez gene - 16796 See in Manteia. MGI - MGI:109656 RefSeq - NM_010688 RefSeq - XM_006532341 RefSeq - XM_006532342 RefSeq Peptide - NP_034818 swissprot - A2A6G7 swissprot - A2A6G6 swissprot - A2A6G5 swissprot - A2A6G4 swissprot - E9Q0N6 swissprot - A2A6G2 swissprot - A2A6G0 swissprot - Q543N3 swissprot - Q61792 swissprot - A2A6G3 swissprot - A2A6H1 swissprot - A2A6H0 swissprot - A2A6G9 swissprot - A2A6G8 Ensembl - ENSMUSG00000038366

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
lasp1	ENSDARG00000057867	Danio rerio
LASP1	ENSGALG00000039299	Gallus gallus
LASP1	ENSG00000002834	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Nebl / Q0II04 / Q9DC07 / LIM zinc-binding domain-containing Nebulette	ENSMUSG00000053702	65
Neb / nebulin / P20929*	ENSMUSG00000026950	36
Nrap / Q80XB4 / Nebulin-related-anchoring protein / Q86VF7*	ENSMUSG00000049134	10

Protein motifs (from Interpro)

Interpro ID	Name
IPR000900	Nebulin repeat
IPR001452	SH3 domain
IPR001781	Zinc finger, LIM-type
IPR035630	Lasp1, SH3 domain
IPR036028	SH3-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	ISS
biological_process	GO:0034220	ion transmembrane transport	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005856	cytoskeleton	IEA
cellular_component	GO:0005925	focal adhesion	IDA
cellular_component	GO:0005938	cell cortex	IEA
cellular_component	GO:0030864	cortical actin cytoskeleton	IEA
molecular_function	GO:0003779	actin binding	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0015075	ion transmembrane transporter activity	ISS
molecular_function	GO:0045296	cadherin binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA
molecular_function	GO:0051015	actin filament binding	IDA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000111	cleft palate	"congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]	Show Allelic Composition: Tyr^c-p/Tyr^c Genetic Background: Not Specified
MP:0000157	abnormal sternum morphology	"malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]	Show Allelic Composition: Tyr^c-p/Tyr^c Genetic Background: Not Specified
MP:0000161	scoliosis	"lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]	Show Allelic Composition: Scn8a^6J/Scn8a^6J Genetic Background: C57BL/6J-Scn8a^6J/J Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma} Genetic Background: involves: C57BL/6
MP:0000274	enlarged heart	"increase over normal size of the heart" [J:29971]	Show Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1
MP:0000503	excessive digestive secretion	"increase in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]	Show Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1 Allelic Composition: Lasp1^tm1Chew/Lasp1^tm1Chew Genetic Background: B6.129X1-Lasp1^tm1Chew
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma} Genetic Background: involves: C57BL/6
MP:0001148	enlarged testes	"increased size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]	Show Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1
MP:0001157	small seminal gland	"reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Wt1^tm1Mlh/Wt1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * MF1
MP:0002111	abnormal tail morphology	"abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tyr^c-p/Tyr^c Genetic Background: Not Specified
MP:0003049	abnormal lumbar vertebrae morphology	"malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma},Pax1^un-ex/Pax1^un-ex Genetic Background: involves: C57BL/6
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma} Genetic Background: involves: C57BL/6
MP:0003639	abnormal response to vitamins	"altered ability or inability to respond to or metabolize a group of organic substances that are required in trace amounts for the normal metabolic homeostasis of the body " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma} Genetic Background: involves: C57BL/6
MP:0004173	abnormal intervertebral disk morphology	"malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma} Genetic Background: involves: C57BL/6
MP:0004606	absent vertebral spinous process	"missing the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma} Genetic Background: involves: C57BL/6
MP:0004624	abnormal thoracic cage	"any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma},Pax1^un-ex/Pax1^un-ex Genetic Background: involves: C57BL/6
MP:0004626	vertebral compression	"appearance of vertebrae that are flattened laterally along the whole length such that they appear pressed together and take up less rostrocaudal space " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma},Pax1^un-ex/Pax1^un-ex Genetic Background: involves: C57BL/6
MP:0004647	decreased lumbar vertebrae number	"reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]	Show Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma} Genetic Background: involves: C57BL/6
MP:0004706	short vertebral body	"reduced length of the main cylindrical portion of the vertebra ventral to the vertebral canal" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma} Genetic Background: involves: C57BL/6
MP:0005226	abnormal vertebral arch development	"anomalous formation of the posterior projection from the body of a vertebra that encloses the vertebral foramen " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Scn8a^6J/Scn8a^6J Genetic Background: C57BL/6J-Scn8a^6J/J
MP:0005297	spina bifida occulta	"common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma} Genetic Background: involves: C57BL/6
MP:0006394	abnormal vertebral epiphyseal plate morphology	"any structural anomaly in the lateral cartilaginous centers of ossification; may be found on the lateral, upper, and/or lower surfaces of the vertebrae at different times during development" [ISBN:0-914294-08-3 "Gray s Anatomy", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma} Genetic Background: involves: C57BL/6
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lasp1^{Tg(Col1a1-lacZ)1Ngma}/Lasp1^{Tg(Col1a1-lacZ)1Ngma} Genetic Background: involves: C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr