Manteia

ENSMUSG00000038372

Mus musculus

Features

Gene ID:	ENSMUSG00000038372

Biological name :	Gmds

Synonyms :	GDP-mannose 4, 6-dehydratase / Gmds / Q8K0C9

Possible biological names infered from orthology :	O60547

Species:	Mus musculus

Chr. number:	13
Strand:	-1
Band:	A3.2
Gene start:	31819579
Gene end:	32338740

Corresponding Affymetrix probe sets:	10408531 (MoGene1.0st) 1434158_at (Mouse Genome 430 2.0 Array) 1439428_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000036696 Ensembl peptide - ENSMUSP00000136223 NCBI entrez gene - 218138 See in Manteia. MGI - MGI:1891112 RefSeq - NM_146041 RefSeq - XM_006516656 RefSeq Peptide - NP_666153 swissprot - J3QMC6 swissprot - Q8K0C9 Ensembl - ENSMUSG00000038372

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
gmds	ENSDARG00000026629	Danio rerio
	ENSGALG00000029497	Gallus gallus
	ENSGALG00000033170	Gallus gallus
GMDS	ENSG00000112699	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR006368	GDP-mannose 4,6-dehydratase
IPR016040	NAD(P)-binding domain
IPR036291	NAD(P)-binding domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007219	Notch signaling pathway	ISS
biological_process	GO:0019673	GDP-mannose metabolic process	ISS
biological_process	GO:0042351	"de novo" GDP-L-fucose biosynthetic process	ISS
cellular_component	GO:0005575	cellular_component	ND
molecular_function	GO:0008446	GDP-mannose 4,6-dehydratase activity	ISS
molecular_function	GO:0016829	lyase activity	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0070401	NADP+ binding	IEA

Pathways (from Reactome)

Pathway description

GDP-fucose biosynthesis

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000322	increased granulocyte number	"greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0000480	increased number of ribs	"greater than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0002968	increased circulating alkaline phosphatase level	"elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003019	increased circulating chloride level	"elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0003884	decreased macrophage count	"fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005015	increased T cell number	"greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005018	decreased T cell number	"fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0005560	decreased circulating glucose level	"less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008039	increased NK T cell number	"greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008045	decreased NK cell number	"reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008075	decreased CD4-positive T cell number	"reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008079	decreased CD8-positive T cell number	"reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008127	decreased dendritic cell number	"reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008210	increased mature B cell number	"greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008346	increased gamma-delta T cell number	"greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0008810	increased circulating iron level	"elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010169	decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number	"a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release" [ISBN:0781735149]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0010851	decreased effector memory CD8-positive, alpha-beta T cell number	"reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0012764	increased alpha-beta T cell number	"greater number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0012765	decreased alpha-beta T cell number	"reduced number of T cells that expresses an alpha-beta T cell receptor complex" [CL:0000789]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0012768	decreased KLRG1-positive NK cell number	"decrease in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation" [MGI:Annie_Speak, PMID:19479342]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013022	increased Ly6C high monocyte number	"increase in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013026	decreased Ly6C low monocyte number	"decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013155	decreased KLRG1+ CD8 alpha beta T cell number	"decrease in the number of CD8+ alpha beta T cells that express KLRG1, a marker of effector and memory T cells" [MGI:csmith]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013435	decreased CD8-positive, naive alpha-beta T cell number	"reduction in the number of the naÃ¯ve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype" [IMPC:Saran]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013511	increased CD4-negative NK T cell number	"increase in the number of CD4-negative NK T cells" [MGI:Saran]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013519	decreased CD4-positive NK T cell number	"reduction in the number of CD4-positive NK T cells" [MGI:Saran]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd
MP:0013692	increased CD5-positive Ly6C-positive T cell number	"increase in the number of CD5-positive T cells expressing the memory marker Ly6C" [MGI:Saran]	Show Allelic Composition: Fgfr1^{tm1.1(KOMP)Vlcg}/Fgfr1^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Fgfr1^{tm1.1(KOMP)Vlcg}/Ucd

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr