ENSMUSG00000038462


Mus musculus

Features
Gene ID: ENSMUSG00000038462
  
Biological name :Uqcrfs1
  
Synonyms : Q9CR68 / ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 / Uqcrfs1
  
Possible biological names infered from orthology : P47985
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.2
Gene start: 30540308
Gene end: 30545362
  
Corresponding Affymetrix probe sets: 10408487 (MoGene1.0st)   1450968_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045284
NCBI entrez gene - 66694     See in Manteia.
MGI - MGI:1913944
RefSeq - NM_025710
RefSeq Peptide - NP_079986
swissprot - Q9CR68
Ensembl - ENSMUSG00000038462
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uqcrfs1ENSDARG00000007745Danio rerio
 Q5ZLR5ENSGALG00000025819Gallus gallus
 P47985ENSG00000169021Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004192  Cytochrome b-c1 complex subunit Rieske, transmembrane domain
 IPR005805  Rieske iron-sulphur protein, C-terminal
 IPR006317  Ubiquinol-cytochrome c reductase, iron-sulphur subunit
 IPR011070  Globular protein, non-globular alpha/beta subunit
 IPR014349  Rieske iron-sulphur protein
 IPR015248  Ubiquinol-cytochrome c reductase 8kDa, N-terminal
 IPR017941  Rieske [2Fe-2S] iron-sulphur domain
 IPR036922  Rieske [2Fe-2S] iron-sulphur domain superfamily
 IPR037008  Cytochrome b-c1 complex subunit Rieske, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0005750 mitochondrial respiratory chain complex III IEA
 cellular_componentGO:0005751 mitochondrial respiratory chain complex IV ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0070469 respiratory chain IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008121 ubiquinol-cytochrome-c reductase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051537 2 iron, 2 sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0000859 abnormal somatosensory cortex morphology "any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0003690 abnormal glial cell physiology "anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0006038 increased mitochondrial proliferation "greater than normal reproduction of mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0008238 abnormal dorsoventral coat patterning "irregular or unusual pigmentation pattern of the dorsal-to-ventral axis compared to control animals" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat6tm1Aki/Stat6tm1Aki
Genetic Background: C.129P2-Stat6tm1Aki Nfkbiztm1Aki

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1+
Genetic Background: Not Specified

 MP:0010009 abnormal piriform cortex morphology 
Show

Allelic Composition: Uqcrfs1tm1Ctm/Uqcrfs1tm1Ctm,Tg(Camk2a-cre)#Szi/0
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J * CBA

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

 MP:0020234 decreased basal metabolism "decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [GOC:NV]
Show

Allelic Composition: Pex11btm1Sjg/Pex11btm1Sjg
Genetic Background: B6.129-Pex11btm1Sjg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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