ENSMUSG00000038542


Mus musculus

Features
Gene ID: ENSMUSG00000038542
  
Biological name :Pcid2
  
Synonyms : Pcid2 / PCI domain-containing protein 2 / Q8BFV2
  
Possible biological names infered from orthology : PCI domain containing 2 / Q5JVF3
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: A1.1
Gene start: 13077189
Gene end: 13105459
  
Corresponding Affymetrix probe sets: 10577096 (MoGene1.0st)   1435586_at (Mouse Genome 430 2.0 Array)   1435587_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000128207
Ensembl peptide - ENSMUSP00000133204
Ensembl peptide - ENSMUSP00000130059
Ensembl peptide - ENSMUSP00000127622
NCBI entrez gene - 234069     See in Manteia.
MGI - MGI:2443003
RefSeq - NM_178708
RefSeq Peptide - NP_848823
swissprot - E9Q1H5
swissprot - F6QZZ3
swissprot - E9Q5V9
swissprot - Q8BFV2
Ensembl - ENSMUSG00000038542
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcid2ENSDARG00000013802Danio rerio
 PCID2ENSGALG00000016831Gallus gallus
 PCID2ENSG00000126226Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000717  Proteasome component (PCI) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery IBA
 biological_processGO:0006368 transcription elongation from RNA polymerase II promoter IBA
 biological_processGO:0016973 poly(A)+ mRNA export from nucleus IBA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043488 regulation of mRNA stability IEA
 biological_processGO:0045579 positive regulation of B cell differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0071033 nuclear retention of pre-mRNA at the site of transcription IBA
 biological_processGO:0090267 positive regulation of mitotic cell cycle spindle assembly checkpoint IEA
 biological_processGO:2000117 negative regulation of cysteine-type endopeptidase activity IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005643 nuclear pore IBA
 cellular_componentGO:0035327 transcriptionally active chromatin IBA
 cellular_componentGO:0070390 transcription export complex 2 IBA
 molecular_functionGO:0003690 double-stranded DNA binding IBA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0002227 abnormal spleen capsule morphology "anomalous structure of the connective tissue that surrounds the spleen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0008174 decreased follicular B cell number "reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes" [CL:0000843, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Pcid2tm1Imku/Pcid2tm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Pcid2tm1Imku/Pcid2tm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Pcid2tm1Imku/Pcid2tm1Imku,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0008477 decreased spleen red pulp amount "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

 MP:0014078 small intestinal villus atrophy "erosion or abnormal flattening of the surface secondary to the shortening and blunting of the small intestinal villi; villus atrophy is a non-specific reaction of the intestinal mucosa to a variety of injuries; the pathogenesis is either associated with a hyper-regenerative increase in crypt cell mitoses leading to crypt elongation or it results from hyporegeneration, that is, reduced mitotic rate with shortened crypts" [MGI:Anna, PMID:16679353]
Show

Allelic Composition: Otcspf/Otcspf
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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