ENSMUSG00000038593


Mus musculus

Features
Gene ID: ENSMUSG00000038593
  
Biological name :Tctn1
  
Synonyms : Q8BZ64 / Tctn1 / Tectonic-1
  
Possible biological names infered from orthology : Q2MV58 / tectonic family member 1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 122237848
Gene end: 122264460
  
Corresponding Affymetrix probe sets: 10533444 (MoGene1.0st)   10533446 (MoGene1.0st)   1429066_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114820
Ensembl peptide - ENSMUSP00000107367
NCBI entrez gene - 654470     See in Manteia.
MGI - MGI:3603820
RefSeq - NM_001039153
RefSeq Peptide - NP_001034242
swissprot - D6RDQ2
swissprot - Q8BZ64
Ensembl - ENSMUSG00000038593
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tctn1ENSDARG00000078447Danio rerio
 TCTN1ENSGALG00000041861Gallus gallus
 TCTN1ENSG00000204852Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tctn3 / Q8R2Q6 / Tectonic-3 / Q6NUS6* / tectonic family member 3*ENSMUSG0000002500828


Protein motifs (from Interpro)
Interpro ID Name
 IPR011677  Domain of unknown function DUF1619


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001841 neural tube formation IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008589 regulation of smoothened signaling pathway IMP
 biological_processGO:0021523 somatic motor neuron differentiation IMP
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0021904 dorsal/ventral neural tube patterning IMP
 biological_processGO:0021956 central nervous system interneuron axonogenesis IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:1904491 protein localization to ciliary transition zone IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0035869 ciliary transition zone IMP
 cellular_componentGO:0036038 MKS complex IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Anchoring of the basal body to the plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000926 absent floor plate "missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0000936 small telencephalic vesicles "reduced size of the paired diverticula of the telencephalon, from which the forebrain develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0004132 absent embryonic cilia "absence of cilia on the cells of the embryonic node " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0005157 holoprosencephaly "presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83058]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005221 abnormal rostral-caudal axis patterning "anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
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Allelic Composition: Atp8a2agil-3J/Atp8a2agil-3J
Genetic Background: CBA/J-Atp8a2agil-3J/GrsrJ

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0012139 increased forebrain size "greater than average size of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Pdgfratm2Sor/Pdgfra+,Plekha1Gt(ROSA)82Sor/Plekha1Gt(ROSA)82Sor
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Tctn1Gt(KST296)Byg/Tctn1Gt(KST296)Byg,Smotm1Amc/Smotm1Amc
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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