ENSMUSG00000038683


Mus musculus

Features
Gene ID: ENSMUSG00000038683
  
Biological name :Pak1ip1
  
Synonyms : p21-activated protein kinase-interacting protein 1 / Pak1ip1 / Q9DCE5
  
Possible biological names infered from orthology : PAK1 interacting protein 1 / Q9NWT1
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.3
Gene start: 41001023
Gene end: 41013015
  
Corresponding Affymetrix probe sets: 10404717 (MoGene1.0st)   1423766_at (Mouse Genome 430 2.0 Array)   1430875_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040846
NCBI entrez gene - 68083     See in Manteia.
MGI - MGI:1915333
RefSeq - NM_026550
RefSeq Peptide - NP_080826
swissprot - Q9DCE5
Ensembl - ENSMUSG00000038683
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q6TNS2ENSDARG00000044488Danio rerio
 PAK1IP1ENSGALG00000012724Gallus gallus
 Q9NWT1ENSG00000111845Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008283 cell proliferation IPI
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0042273 ribosomal large subunit biogenesis IEA
 biological_processGO:0060021 roof of mouth development IMP
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000455 abnormal maxilla morphology "malformation of the upper bony framework of the mouth where the superior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000822 abnormal brain ventricle morphology "malformed or absent fluid filled cavities of the cerebrum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004235 abnormal masseter muscle morphology "any structural anomaly of the masticatory muscle of posterior cheek with origin from the inferior border and medial surface of the zygomatic arch, with insertion into the lateral surface of the ramus of the mandible, with nerve supply from the masseteric nerve, and whose action closes the jaw during chewing" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008797 facial cleft "a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009888 palatal shelves fail to meet at midline "polarized growth towards the midline following palatal shelf elevation does not occur" [PMID:16942766]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012091 increased midbrain size "greater than average size of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes" [MGI:anna, MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012138 decreased forebrain size "size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012263 decreased hindbrain size "size reduction or truncation of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0030095 abnormal midface morphology "any structural anomaly of the midface region which extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base; it is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region; traditionally, the nose and premaxilla are not included in the midface" [HP:0000309, PMID:19125436]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0030197 small nasal septum "reduced size of the dividing wall that runs down the midline of the nose, separating the nasal cavity into the two nostrils" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc/Gt(ROSA)26Sortm9(EGFP/Rpl10a)Amc
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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