ENSMUSG00000039117


Mus musculus

Features
Gene ID: ENSMUSG00000039117
  
Biological name :Taf4
  
Synonyms : Taf4 / TATA-box binding protein associated factor 4
  
Possible biological names infered from orthology : O00268
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H4
Gene start: 179912152
Gene end: 179976646
  
Corresponding Affymetrix probe sets: 10490352 (MoGene1.0st)   1427460_at (Mouse Genome 430 2.0 Array)   1452438_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153863
Ensembl peptide - ENSMUSP00000038610
NCBI entrez gene - 228980     See in Manteia.
MGI - MGI:2152346
RefSeq - NM_001081092
RefSeq - XM_006500588
RefSeq Peptide - NP_001074561
swissprot - E9QAP7
Ensembl - ENSMUSG00000039117
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 taf4aENSDARG00000068192Danio rerio
 TAF4ENSGALG00000005121Gallus gallus
 TAF4ENSG00000130699Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Taf4b / G5E8Z2 / Transcription initiation factor TFIID subunit 4B / Q92750* / TATA-box binding protein associated factor 4b*ENSMUSG0000005432128


Protein motifs (from Interpro)
Interpro ID Name
 IPR003894  TAFH/NHR1
 IPR007900  Transcription initiation factor TFIID component TAF4
 IPR009072  Histone-fold
 IPR037249  TAFH/NHR1 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0006352 DNA-templated transcription, initiation IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II TAS
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IBA
 biological_processGO:0051123 RNA polymerase II transcriptional preinitiation complex assembly IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005669 transcription factor TFIID complex IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0033276 transcription factor TFTC complex IEA
 cellular_componentGO:0071339 MLL1 complex IEA
 molecular_functionGO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0003713 transcription coactivator activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IBA
 molecular_functionGO:0017162 aryl hydrocarbon receptor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
RNA Polymerase II Pre-transcription Events
Regulation of TP53 Activity through Phosphorylation
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0000416 sparse fur "fur that is significantly less dense" [J:46854]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0001201 translucent skin "skin that is more transparent to light than normal " [J:15108]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0001247 dermal cysts "abnormal membranous sacs appearing in the dermis" [J:53379]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Taf4tm1Idvd/Taf4tm1Idvd,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Taf4tm1Idvd/Taf4tm1Idvd,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003853 dry skin "skin characterized by the lack of natural or normal moisture" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Taf4tm1Idvd/Taf4tm1Idvd,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Taf4tm1Idvd/Taf4tm1Idvd,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Taf4tm1Idvd/Taf4tm1Idvd,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Taf4tm1Idvd/Taf4tm1Idvd,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Raratm1Ipc/Raratm1Ipc,Rargtm2Ipc/Rargtm2Ipc
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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