ENSMUSG00000039233


Mus musculus

Features
Gene ID: ENSMUSG00000039233
  
Biological name :Tbce
  
Synonyms : Q8CIV8 / Tbce / Tubulin-specific chaperone E
  
Possible biological names infered from orthology : Q15813 / tubulin folding cofactor E
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A1
Gene start: 13997949
Gene end: 14039638
  
Corresponding Affymetrix probe sets: 10407814 (MoGene1.0st)   1428282_at (Mouse Genome 430 2.0 Array)   1445668_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125613
Ensembl peptide - ENSMUSP00000047880
Ensembl peptide - ENSMUSP00000125244
NCBI entrez gene - 70430     See in Manteia.
MGI - MGI:1917680
RefSeq - XM_017315601
RefSeq - NM_178337
RefSeq - XM_006516773
RefSeq - XM_006516775
RefSeq - XM_011244347
RefSeq Peptide - NP_848027
swissprot - E0CZ81
swissprot - E0CXJ6
swissprot - Q8CIV8
Ensembl - ENSMUSG00000039233
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tbceENSDARG00000099921Danio rerio
 ENSGALG00000013950Gallus gallus
 TBCEENSG00000284770Homo sapiens
 TBCEENSG00000285053Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tbcel / Q8C5W3 / Mus musculus tubulin folding cofactor E-like (Tbcel), transcript variant 3, mRNA. / Q5QJ74* / AP000646.1* / tubulin folding cofactor E like*ENSMUSG0000003728720


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR000938  CAP Gly-rich domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036859  CAP Gly-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization ISO
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0007021 tubulin complex assembly TAS
 biological_processGO:0007023 post-chaperonin tubulin folding pathway ISO
 biological_processGO:0007052 mitotic spindle organization ISS
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0014889 muscle atrophy IMP
 biological_processGO:0048589 developmental growth IMP
 biological_processGO:0048936 peripheral nervous system neuron axonogenesis IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0051082 unfolded protein binding TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000748 progressive muscle weakness "increasing loss of strength over time" [MGI:CLS, J:67994]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001078 abnormal phrenic nerve "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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