ENSMUSG00000039497


Mus musculus

Features
Gene ID: ENSMUSG00000039497
  
Biological name :Dse
  
Synonyms : Dermatan-sulfate epimerase / Dse / Q8BLI4
  
Possible biological names infered from orthology : Q9UL01
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B1
Gene start: 34151393
Gene end: 34207715
  
Corresponding Affymetrix probe sets: 10368647 (MoGene1.0st)   1455795_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149947
Ensembl peptide - ENSMUSP00000150789
Ensembl peptide - ENSMUSP00000040074
NCBI entrez gene - 212898     See in Manteia.
MGI - MGI:2443455
RefSeq - XM_006512651
RefSeq - XM_006512652
RefSeq - XM_011243156
RefSeq - NM_172508
RefSeq Peptide - NP_766096
swissprot - Q8BLI4
swissprot - A0A1L1SSJ9
swissprot - A0A1L1SUI1
Ensembl - ENSMUSG00000039497
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dseENSDARG00000017988Danio rerio
 ENSGALG00000014963Gallus gallus
 DSEENSG00000111817Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dsel / Q0VBN2 / Dermatan-sulfate epimerase-like protein / Q8IZU8* / dermatan sulfate epimerase-like*ENSMUSG0000003870240


Protein motifs (from Interpro)
Interpro ID Name
 IPR008929  Chondroitin AC/alginate lyase
 IPR032518  Heparinase II, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015012 heparan sulfate proteoglycan biosynthetic process IEA
 biological_processGO:0030206 chondroitin sulfate biosynthetic process IEA
 biological_processGO:0030208 dermatan sulfate biosynthetic process ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0047757 chondroitin-glucuronate 5-epimerase activity IEA


Pathways (from Reactome)
Pathway description
Dermatan sulfate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0003089 reduced skin tensile strength "reduction in the normal maximum tension the skin can withstand without tearing" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:48068]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0003705 abnormal hypodermis morphology "malformed or atypical condition of the innermost and thickest layer of the skin composed of loose connective tissue containing adipoctyes" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0008438 abnormal cutaneous collagen fibril morphology "any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc30a3tm1Rpa/Slc30a3tm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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