| MP:0000043 | organ of Corti degeneration | "a retrogressive impairment of function or destruction of the highly specialized epithelium in the floor of the ductus cochlearis" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Enamtm1.1Jcch/Enam+
Genetic Background: involves: C57BL/6
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| MP:0001489 | decreased startle reflex | "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3] |
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Allelic Composition: Myo7apolka/Myo7apolka
Genetic Background: involves: C57BL/6J
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| MP:0001967 | deafness | "inability to hear" [J:57651] |
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Allelic Composition: Enamtm1.1Jcch/Enam+
Genetic Background: involves: C57BL/6
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| MP:0002857 | cochlear ganglion degeneration | "loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Enamtm1.1Jcch/Enam+
Genetic Background: involves: C57BL/6
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| MP:0004362 | cochlear hair cell degeneration | "degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Enamtm1.1Jcch/Enam+
Genetic Background: involves: C57BL/6
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| MP:0004398 | cochlear inner hair cell degeneration | "degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Enamtm1.1Jcch/Enam+
Genetic Background: involves: C57BL/6
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| MP:0004399 | abnormal cochlear outer hair cell morphology | "any structural abnormality in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell s surface through the cuticular plate into the tectorial membrane" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Enamtm1.1Jcch/Enam+
Genetic Background: involves: C57BL/6
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| MP:0004404 | cochlear outer hair cell degeneration | "degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Enamtm1.1Jcch/Enam+
Genetic Background: involves: C57BL/6
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| MP:0004411 | decreased endocochlear potential | "reduction of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Enamtm1.1Jcch/Enam+
Genetic Background: involves: C57BL/6
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| MP:0004491 | abnormal orientation of outer hair cell stereociliary bundles | "misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium " [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Enamtm1.1Jcch/Enam+
Genetic Background: involves: C57BL/6
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| MP:0004528 | fused outer hair cell stereocilia | "coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells, often resulting in giant stereocilia" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Enamtm1.1Jcch/Enam+
Genetic Background: involves: C57BL/6
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| MP:0004597 | increased susceptibility to noise-induced hearing loss | "greater than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J
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| MP:0004628 | Dieters cell degeneration | "degeneration or loss of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Enamtm1.1Jcch/Enam+
Genetic Background: involves: C57BL/6
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| MP:0004737 | absent distortion product otoacoustic emissions | "failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Enamtm1.1Jcch/Enam+
Genetic Background: involves: C57BL/6
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| MP:0004749 | nonsyndromic hearing loss | "a form of progressive hearing loss that is not associated with visible abnormalities of the external ear or other signs and symptoms; the vast majority of hereditary hearing loss is nonsyndromic and can be associated with abnormalities of the middle ear and/or inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: Enamtm1.1Jcch/Enam+
Genetic Background: involves: C57BL/6
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| MP:0011967 | increased or absent threshold for auditory brainstem response | "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith] |
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Allelic Composition: Myo7apolka/Myo7apolka
Genetic Background: involves: C57BL/6J
Allelic Composition: Usp53mbo/Usp53mbo
Genetic Background: involves: BALB/cByJ * C57BL/6J
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