ENSMUSG00000039713


Mus musculus

Features
Gene ID: ENSMUSG00000039713
  
Biological name :Plekhg5
  
Synonyms : Pleckstrin homology domain-containing family G member 5 / Plekhg5 / Q66T02
  
Possible biological names infered from orthology : O94827 / pleckstrin homology and RhoGEF domain containing G5
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 152072498
Gene end: 152115400
  
Corresponding Affymetrix probe sets: 10510643 (MoGene1.0st)   1452248_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112707
Ensembl peptide - ENSMUSP00000081132
Ensembl peptide - ENSMUSP00000101286
Ensembl peptide - ENSMUSP00000101287
NCBI entrez gene - 269608     See in Manteia.
MGI - MGI:2652860
RefSeq - XM_011250266
RefSeq - XM_006538925
RefSeq - XM_006538926
RefSeq - XM_006538927
RefSeq - XM_006538928
RefSeq - NM_001285999
RefSeq - XM_006538923
RefSeq Peptide - NP_001272928
swissprot - B1AS67
swissprot - A0A0A0MQC2
swissprot - Q66T02
Ensembl - ENSMUSG00000039713
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plekhg5aENSDARG00000025902Danio rerio
 plekhg5bENSDARG00000101752Danio rerio
 PLEKHG5ENSGALG00000027476Gallus gallus
 O94827ENSG00000171680Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8R0J1 / Plekhg6 / Pleckstrin homology domain-containing family G member 6 / Q3KR16* / pleckstrin homology and RhoGEF domain containing G6*ENSMUSG0000003816725


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035767 endothelial cell chemotaxis IMP
 biological_processGO:0043542 endothelial cell migration IDA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

 MP:0003410 abnormal artery development "anomaly in the process of forming the blood vessels that carry blood away from the heart" [J:94740, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkal1Gt(6062)Tgen/Cdkal1Gt(6062)Tgen
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA/JNCrj

 MP:0010551 abnormal coronary vessel morphology "any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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