ENSMUSG00000039714


Mus musculus

Features
Gene ID: ENSMUSG00000039714
  
Biological name :Cplx3
  
Synonyms : Complexin-3 / Cplx3 / Q8R1B5
  
Possible biological names infered from orthology : Q8WVH0
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: B
Gene start: 57599992
Gene end: 57606281
  
Corresponding Affymetrix probe sets: 10593947 (MoGene1.0st)   1424606_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046748
Ensembl peptide - ENSMUSP00000150682
Ensembl peptide - ENSMUSP00000149521
NCBI entrez gene - 235415     See in Manteia.
MGI - MGI:2384571
RefSeq - NM_146223
RefSeq Peptide - NP_666335
swissprot - A0A1L1SUC8
swissprot - A0A1L1SRL3
swissprot - Q8R1B5
Ensembl - ENSMUSG00000039714
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cplx3aENSDARG00000062508Danio rerio
 cplx3bENSDARG00000089486Danio rerio
 CPLX3ENSGALG00000026446Gallus gallus
 CPLX3ENSG00000213578Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cplx4 / Q80WM3 / Complexin-4 / Q7Z7G2*ENSMUSG0000002451963


Protein motifs (from Interpro)
Interpro ID Name
 IPR008849  Synaphin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006836 neurotransmitter transport IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0016079 synaptic vesicle exocytosis IMP
 biological_processGO:0030073 insulin secretion IMP
 biological_processGO:0046928 regulation of neurotransmitter secretion IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IDA
 cellular_componentGO:0098793 presynapse IEA
 molecular_functionGO:0000149 SNARE binding IDA
 molecular_functionGO:0005326 neurotransmitter transporter activity IMP
 molecular_functionGO:0019905 syntaxin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Aifm1tm2.1Pngr/Aifm1tm2.1Pngr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001900 impaired synaptic plasticity "decreased or inability of the nervous system to change its reactivity as a result of successive activations " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aifm1tm2.1Pngr/Aifm1tm2.1Pngr
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Foxs1tm1Kmor/Foxs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JJcl

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0005445 abnormal neurotransmitter release "aberration in the secretion of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Foxs1tm1Kmor/Foxs1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6JJcl

Allelic Composition: Cplx3tm1Rmnd/Cplx3tm1Rmnd,Cplx4tm1Bros/Cplx4tm1Bros
Genetic Background: involves: C57BL/6

 MP:0008520 disorganized retinal outer plexiform layer "a derangement of the normal pattern of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Cplx3tm1Rmnd/Cplx3tm1Rmnd,Cplx4tm1Bros/Cplx4tm1Bros
Genetic Background: involves: C57BL/6

 MP:0010746 abnormal pre-Botzinger complex physiology "any functional anomaly of the group of interneurons within the medulla oblongata s ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis" [PMID:18826652]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd,Cplx3tm1Rmnd/Cplx3tm1Rmnd
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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