ENSMUSG00000039740


Mus musculus

Features
Gene ID: ENSMUSG00000039740
  
Biological name :Alg2
  
Synonyms : Alg2 / Alpha-1,3/1,6-mannosyltransferase ALG2 / Q9DBE8
  
Possible biological names infered from orthology : ALG2, alpha-1,3/1,6-mannosyltransferase / Q9H553
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B1
Gene start: 47465067
Gene end: 47474333
  
Corresponding Affymetrix probe sets: 10512847 (MoGene1.0st)   1421059_a_at (Mouse Genome 430 2.0 Array)   1433144_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043580
Ensembl peptide - ENSMUSP00000121934
NCBI entrez gene - 56737     See in Manteia.
MGI - MGI:1914731
RefSeq - NM_019998
RefSeq - XM_006538124
RefSeq Peptide - NP_064382
swissprot - F6RBY3
swissprot - Q9DBE8
Ensembl - ENSMUSG00000039740
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 alg2ENSDARG00000070399Danio rerio
 ALG2ENSGALG00000013573Gallus gallus
 ALG2ENSG00000119523Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001296  Glycosyl transferase, family 1
 IPR028098  Glycosyltransferase subfamily 4-like, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006488 dolichol-linked oligosaccharide biosynthetic process IEA
 biological_processGO:0006490 oligosaccharide-lipid intermediate biosynthetic process IBA
 biological_processGO:0033577 protein glycosylation in endoplasmic reticulum IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0097502 mannosylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000033 alpha-1,3-mannosyltransferase activity IEA
 molecular_functionGO:0004378 GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA
 molecular_functionGO:0102704 GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase activity IEA


Pathways (from Reactome)
Pathway description
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

Allelic Composition: Alg2tm1Lex/Alg2tm1Lex
Genetic Background: B6;129S5-Alg2tm1Lex/Mmucd

 MP:0011275 abnormal behavioral response to light "unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light" [GO:0009416, MGI:llw2]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

 MP:0011806 decreased dermal fibroblast proliferation "reduction in the expansion rate of a dermal fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Alg2tm1Lex/Alg2tm1Lex
Genetic Background: B6;129S5-Alg2tm1Lex/Mmucd

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Adipor1tm1b(EUCOMM)Hmgu/Adipor1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Adipor1tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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