Manteia

ENSMUSG00000039768

Mus musculus

Features

Gene ID:	ENSMUSG00000039768

Biological name :	Dnajc11

Synonyms :	Dnajc11 / DnaJ homolog subfamily C member 11 / Q5U458

Possible biological names infered from orthology :	DnaJ heat shock protein family (Hsp40) member C11 / Q9NVH1

Species:	Mus musculus

Chr. number:	4
Strand:	1
Band:	E2
Gene start:	151933691
Gene end:	151982137

Corresponding Affymetrix probe sets:	10510604 (MoGene1.0st) 1433880_at (Mouse Genome 430 2.0 Array) 1433881_at (Mouse Genome 430 2.0 Array) 1439763_at (Mouse Genome 430 2.0 Array) 1447055_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000051643 Ensembl peptide - ENSMUSP00000122140 Ensembl peptide - ENSMUSP00000119604 NCBI entrez gene - 230935 See in Manteia. MGI - MGI:2443386 RefSeq - NM_172704 RefSeq - XM_017320184 RefSeq Peptide - NP_766292 swissprot - E9Q8B3 swissprot - Q5U458 swissprot - A2A8D1 Ensembl - ENSMUSG00000039768

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
dnajc11a	ENSDARG00000011196	Danio rerio
dnajc11b	ENSDARG00000102696	Danio rerio
DNAJC11	ENSGALG00000000627	Gallus gallus
Q9NVH1	ENSG00000007923	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001623	DnaJ domain
IPR018253	DnaJ domain, conserved site
IPR024586	DnaJ-like protein C11, C-terminal
IPR036869	Chaperone J-domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0042407	cristae formation	IMP
cellular_component	GO:0001401	mitochondrial sorting and assembly machinery complex	IEA
cellular_component	GO:0005739	mitochondrion	ISO
cellular_component	GO:0005741	mitochondrial outer membrane	ISO
cellular_component	GO:0005743	mitochondrial inner membrane	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0061617	MICOS complex	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0000694	spleen hypoplasia	"small size due to reduced cell number in the spleen" [J:43971]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0000745	tremors	"repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0000748	progressive muscle weakness	"increasing loss of strength over time" [MGI:CLS, J:67994]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0000937	abnormal motor neuron morphology	"malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0001392	abnormal locomotor activity	"altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0001823	thymus hypoplasia	"small size due to reduced cell number in the thymus" [J:23255]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0002875	decreased erythrocyte count	"reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0004263	abnormal limb posture	"atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0004956	decreased thymus weight	"reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0005090	increased double-negative T cells count	"greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0005092	decreased double-positive T cell count	"less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0008025	brain vacuoles	"the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0008074	increased CD4-positive T cell number	"greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0008078	increased CD8-positive T cell number	"greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0010129	increased DN1 thymic pro-T cell number	"increased number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative" [CL:0000894]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0011636	disorganized mitochondrial cristae	"derangement of the pattern of the inward folds of the mitochondrial inner membrane" [MGI:csmith]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0012051	spasticity	"a motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes and increased resistance to stretch" [HP:0001257, MGI:csmith]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0013585	thymus cortex atrophy	"acquired diminution of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:Anna]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
MP:0013590	enlarged thymus medulla	"increased size of the inner area of thymus lobules" [MGI:Anna]	Show Allelic Composition: Dicer1^tm1.1Doca/Dicer1^tm1.1Doca Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr