ENSMUSG00000039781


Mus musculus

Features
Gene ID: ENSMUSG00000039781
  
Biological name :Cep131
  
Synonyms : Centrosomal protein of 131 kDa / Cep131 / Q62036
  
Possible biological names infered from orthology : centrosomal protein 131 / Q9UPN4
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120064430
Gene end: 120086827
  
Corresponding Affymetrix probe sets: 10393687 (MoGene1.0st)   1419216_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000136392
Ensembl peptide - ENSMUSP00000101834
Ensembl peptide - ENSMUSP00000101836
NCBI entrez gene - 12009     See in Manteia.
MGI - MGI:107440
RefSeq - XM_006532061
RefSeq - XM_011248684
RefSeq - XM_011248685
RefSeq - NM_009734
RefSeq Peptide - NP_033864
swissprot - Q62036
swissprot - B1AXI9
swissprot - J3QMP9
Ensembl - ENSMUSG00000039781
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cep131ENSDARG00000088984Danio rerio
 CEP131ENSGALG00000006895Gallus gallus
 CEP131ENSG00000141577Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR030465  Centrosomal protein of 131kDa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis TAS
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0007288 sperm axoneme assembly IMP
 biological_processGO:0008284 positive regulation of cell proliferation ISS
 biological_processGO:0010824 regulation of centrosome duplication IBA
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035735 intraciliary transport involved in cilium assembly IEA
 biological_processGO:0042073 intraciliary transport IMP
 biological_processGO:0071539 protein localization to centrosome ISO
 biological_processGO:0090316 positive regulation of intracellular protein transport ISO
 biological_processGO:1905198 manchette assembly IMP
 biological_processGO:1905515 non-motile cilium assembly IMP
 biological_processGO:1990953 intramanchette transport IMP
 cellular_componentGO:0001669 acrosomal vesicle IDA
 cellular_componentGO:0002177 manchette IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015630 microtubule cytoskeleton ISO
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034451 centriolar satellite ISS
 cellular_componentGO:0035869 ciliary transition zone ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 cellular_componentGO:0045171 intercellular bridge ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0044877 protein-containing complex binding IDA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008892 abnormal sperm flagellum "any strucutral anomaly of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility" [MESH:A05.360.490.890.840]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009231 detached acrosome "detachment or loss of adhesion of the acrosome cap from the sperm head nucleus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009830 abnormal sperm connecting piece morphology "any structural abnormality in the segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum" [PMID:14581499]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009838 abnormal sperm axoneme morphology "any structural abnormality of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion" [PMID:14581499]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Map3k1goya/Map3k1tm1Yxia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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