ENSMUSG00000039834


Mus musculus

Features
Gene ID: ENSMUSG00000039834
  
Biological name :Zfp335
  
Synonyms : A2A5K6 / Zfp335 / zinc finger protein 335
  
Possible biological names infered from orthology : Q9H4Z2 / ZNF335
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H3
Gene start: 164891882
Gene end: 164911757
  
Corresponding Affymetrix probe sets: 10489591 (MoGene1.0st)   1453039_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038298
Ensembl peptide - ENSMUSP00000138664
Ensembl peptide - ENSMUSP00000139133
NCBI entrez gene - 329559     See in Manteia.
MGI - MGI:2682313
RefSeq - XM_017319059
RefSeq - NM_199027
RefSeq - XM_006499798
RefSeq - XM_017319057
RefSeq - XM_017319058
RefSeq Peptide - NP_950192
swissprot - A2A5K6
swissprot - Q6P5F4
swissprot - S4R2J0
Ensembl - ENSMUSG00000039834
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ZNF335ENSDARG00000076920Danio rerio
 ZNF335ENSGALG00000041370Gallus gallus
 Q9H4Z2ENSG00000198026Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctcf / Q61164 / Mus musculus CCCTC-binding factor (Ctcf), transcript variant 2, mRNA. / P49711* / CCCTC-binding factor*ENSMUSG0000000569811
Zfp64 / Q99KE8 / zinc finger protein 64 / Q9NTW7* / Q9NPA5* / ZFP64 zinc finger protein*ENSMUSG0000002755111
Ctcfl / A2APF3 / Transcriptional repressor CTCFL / Q8NI51* / CCCTC-binding factor like*ENSMUSG0000007049510


Protein motifs (from Interpro)
Interpro ID Name
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0002052 positive regulation of neuroblast proliferation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IMP
 biological_processGO:0010468 regulation of gene expression IDA
 biological_processGO:0021895 cerebral cortex neuron differentiation IMP
 biological_processGO:0040029 regulation of gene expression, epigenetic IEA
 biological_processGO:0048812 neuron projection morphogenesis IMP
 biological_processGO:0048854 brain morphogenesis IMP
 biological_processGO:0050671 positive regulation of lymphocyte proliferation IEA
 biological_processGO:0050767 regulation of neurogenesis IMP
 biological_processGO:0050769 positive regulation of neurogenesis IEA
 biological_processGO:0051569 regulation of histone H3-K4 methylation IDA
 biological_processGO:0080182 histone H3-K4 trimethylation IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0035097 histone methyltransferase complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Zfp335Gt(XG241)Byg/Zfp335Gt(XG241)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1

 MP:0003241 loss of cortex neurons "loss of neurons in the cortex region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Zfp335Gt(XG241)Byg/Zfp335Gt(XG241)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Zfp335tm1.1Caw/Zfp335+,Emx1tm1(cre)Krj/Emx1+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1

Allelic Composition: Rag1tm1(GFP)Imku/?,Zfp335blt/Zfp335blt
Genetic Background: involves: C57BL/6 * CBA

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1

 MP:0010836 decreased CD4-positive, alpha-beta memory T cell number "reduced number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000897, GO_REF:0000031, GOC:add, GOC:tfm, http://www.immgen.org/index_content.html, ISBN:0781735149]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1

 MP:0010839 decreased CD8-positive, alpha-beta memory T cell number "decreased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high" [CL:0000909, GO_REF:0000031, GOC:tfm, PMID:20146720]
Show

Allelic Composition: Smad4tm2.1Cxd/Smad4+,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CD-1

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Fbxl5Gt(OST386421)Lex/Fbxl5+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Zfp335Gt(XG241)Byg/Zfp335Gt(XG241)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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