ENSMUSG00000005698


Mus musculus

Features
Gene ID: ENSMUSG00000005698
  
Biological name :Ctcf
  
Synonyms : Ctcf / Mus musculus CCCTC-binding factor (Ctcf), transcript variant 2, mRNA. / Q61164
  
Possible biological names infered from orthology : CCCTC-binding factor / P49711
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: D3
Gene start: 105636568
Gene end: 105682922
  
Corresponding Affymetrix probe sets: 10574812 (MoGene1.0st)   1418330_at (Mouse Genome 430 2.0 Array)   1449042_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005841
NCBI entrez gene - 13018     See in Manteia.
MGI - MGI:109447
RefSeq - XM_017312557
RefSeq - NM_001358924
RefSeq - NM_181322
RefSeq - XM_006530646
RefSeq - XM_006530647
RefSeq - XM_006530648
RefSeq - XM_006530644
RefSeq - XM_006530645
RefSeq Peptide - NP_851839
RefSeq Peptide - NP_001345853
swissprot - Q61164
Ensembl - ENSMUSG00000005698
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctcfENSDARG00000056621Danio rerio
 CTCFENSGALG00000001817Gallus gallus
 CTCFENSG00000102974Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctcfl / A2APF3 / Transcriptional repressor CTCFL / Q8NI51* / CCCTC-binding factor like*ENSMUSG0000007049539
Zfp64 / Q99KE8 / zinc finger protein 64 / Q9NTW7* / Q9NPA5* / ZFP64 zinc finger protein*ENSMUSG0000002755121
A2A5K6 / Zfp335 / zinc finger protein 335 / Q9H4Z2* / ZNF335*ENSMUSG0000003983420


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006306 DNA methylation IMP
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006349 regulation of gene expression by genetic imprinting IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007059 chromosome segregation IEA
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0009048 dosage compensation by inactivation of X chromosome TAS
 biological_processGO:0010216 maintenance of DNA methylation IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0016584 nucleosome positioning ISO
 biological_processGO:0031060 regulation of histone methylation IMP
 biological_processGO:0035065 regulation of histone acetylation IMP
 biological_processGO:0040029 regulation of gene expression, epigenetic ISO
 biological_processGO:0040030 regulation of molecular function, epigenetic ISO
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0071459 protein localization to chromosome, centromeric region ISS
 cellular_componentGO:0000775 chromosome, centromeric region ISO
 cellular_componentGO:0000793 condensed chromosome ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043035 chromatin insulator sequence binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Tmprss6m3Btlr/Tmprss6m3Btlr
Genetic Background: C57BL/6J-Tmprss6m3Btlr

Allelic Composition: Ctcftm1Laat/Ctcf+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tmprss6m3Btlr/Tmprss6m3Btlr
Genetic Background: C57BL/6J-Tmprss6m3Btlr

Allelic Composition: Ctcftm1Laat/Ctcftm1Laat,Tg(Lck-cre)1Cwi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctcftm1Laat/Ctcftm1Laat,Tg(Lck-cre)1Cwi/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * DBA/2J

 MP:0004964 absent inner cell mass "absence of the cells of the blastocyst that develop into the body of the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ctcftm1Laat/Ctcftm1Laat,Tg(Lck-cre)1Cwi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tmprss6m3Btlr/Tmprss6m3Btlr
Genetic Background: C57BL/6J-Tmprss6m3Btlr

Allelic Composition: Ctcftm1Laat/Ctcftm1Laat,Tg(Lck-cre)1Cwi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Tmprss6m3Btlr/Tmprss6m3Btlr
Genetic Background: C57BL/6J-Tmprss6m3Btlr

Allelic Composition: Ctcftm1Laat/Ctcftm1Laat,Tg(Lck-cre)1Cwi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctcftm1Laat/Ctcftm1Laat,Tg(Lck-cre)1Cwi/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * DBA/2J

Allelic Composition: Ctcftm1Laat/Ctcftm1Laat,Rag2tm1Fwa/Rag2tm1Fwa,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * C57BL/10

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmprss6m3Btlr/Tmprss6m3Btlr
Genetic Background: C57BL/6J-Tmprss6m3Btlr

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmprss6m3Btlr/Tmprss6m3Btlr
Genetic Background: C57BL/6J-Tmprss6m3Btlr

Allelic Composition: Ctcftm1Laat/Ctcf+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctcftm1Laat/Ctcftm1Laat,Tg(Lck-cre)1Cwi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctcftm1Laat/Ctcftm1Laat,Tg(Lck-cre)1Cwi/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * DBA/2J

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmprss6m3Btlr/Tmprss6m3Btlr
Genetic Background: C57BL/6J-Tmprss6m3Btlr

Allelic Composition: Ctcftm1Laat/Ctcf+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ctcftm1Laat/Ctcftm1Laat,Tg(Lck-cre)1Cwi/0,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * DBA/2J

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmprss6m3Btlr/Tmprss6m3Btlr
Genetic Background: C57BL/6J-Tmprss6m3Btlr

Allelic Composition: Ctcftm1Laat/Ctcftm1Laat,Tg(Lck-cre)1Cwi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmprss6m3Btlr/Tmprss6m3Btlr
Genetic Background: C57BL/6J-Tmprss6m3Btlr

 MP:0008527 embryonic lethality at implantation "death due to failure of implantation (Mus: E4.5)" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ctcftm1Laat/Ctcf+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ctcftm1Laat/Ctcf+,Tg(Lck-cre)1Cwi/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012102 absent trophectoderm "absence of the outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo s means of nutrition" [MGI:anna]
Show

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Kif18atm1Zgwg/Kif18atm1Zgwg
Genetic Background: either: 129-Kif18atm1Zgwg or (involves: 129 * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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