| MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
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| MP:0000755 | hindlimb paralysis | "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0000807 | abnormal hippocampus morphology | "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0000937 | abnormal motor neuron morphology | "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
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| MP:0000939 | reduced motor neuron number | "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0001443 | poor grooming | "below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [MGI:CLS, J:30404] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0001783 | decreased white fat amount | "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0002184 | abnormal innervation | "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0002269 | muscular atrophy | "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0004087 | abnormal muscle fiber morphology | "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0004091 | abnormal Z lines | "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0008260 | abnormal autophagy | "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0008284 | abnormal hippocampus pyramidal cell layer | |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0008918 | microgliosis | "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0009122 | decreased white fat cell lipid droplet size | "reduction in the size of the single large lipid droplet or vacuole of white fat cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0009133 | decreased white fat cell size | "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0009400 | decreased skeletal muscle fiber size | "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0009404 | centrally nucleated skeletal muscle fibers | "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0009412 | skeletal muscle fiber degeneration | "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0009971 | decreased hippocampus pyramidal cell number | "decreased number of the projection neurons in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
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| MP:0009974 | decreased cerebral cortex pyramidal cell number | "reduced number of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
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| MP:0010047 | axonal spheroids | "focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions" [PMID:15644421] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0010179 | rough coat | "coat does not have the usual smooth appearance" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
|
| MP:0011630 | increased mitochondria size | "enlarged the cellular organelles responsible for energy production" [MGI:csmith] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
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| MP:0011975 | neuronal cytoplasmic inclusions | "presence of aggregates of protein within the cytoplasm of neurons; hallmark of neurodegenerative disorders" [MGI:mnk] |
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Allelic Composition: Hmx3tm1Ebo/Hmx3tm1Ebo
Genetic Background: involves: 129S4/SvJae
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