ENSMUSG00000040151


Mus musculus

Features
Gene ID: ENSMUSG00000040151
  
Biological name :Hs2st1
  
Synonyms : Hs2st1 / Mus musculus heparan sulfate 2-O-sulfotransferase 1 (Hs2st1), transcript variant 1, mRNA. / Q8R3H7
  
Possible biological names infered from orthology : AC093155.3 / heparan sulfate 2-O-sulfotransferase 1 / Q7LGA3
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H2
Gene start: 144429706
Gene end: 144570181
  
Corresponding Affymetrix probe sets: 10502522 (MoGene1.0st)   1422739_at (Mouse Genome 430 2.0 Array)   1440905_at (Mouse Genome 430 2.0 Array)   1450729_at (Mouse Genome 430 2.0 Array)   1450730_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043066
Ensembl peptide - ENSMUSP00000123816
NCBI entrez gene - 23908     See in Manteia.
MGI - MGI:1346049
RefSeq - XM_006501450
RefSeq - NM_001355234
RefSeq - NM_011828
RefSeq - XM_006501449
RefSeq Peptide - NP_035958
RefSeq Peptide - NP_001342163
swissprot - Q8R3H7
swissprot - E0CYX6
Ensembl - ENSMUSG00000040151
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hs2st1aENSDARG00000099478Danio rerio
 hs2st1bENSDARG00000062008Danio rerio
 HS2ST1ENSGALG00000028423Gallus gallus
 AC093155.3ENSG00000267561Homo sapiens
 HS2ST1ENSG00000153936Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ust / Q8BUB6 / uronyl-2-sulfotransferase / Q9Y2C2*ENSMUSG0000004771226


Protein motifs (from Interpro)
Interpro ID Name
 IPR005331  Sulfotransferase
 IPR007734  Heparan sulphate 2-O-sulfotransferase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IMP
 biological_processGO:0030202 heparin metabolic process IMP
 biological_processGO:0060676 ureteric bud formation IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004394 heparan sulfate 2-O-sulfotransferase activity IMP
 molecular_functionGO:0008146 sulfotransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
HS-GAG biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

Allelic Composition: Hs2st1tm1.2Je/Hs2st1tm1.2Je
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Hs2st1tm1.1Je/Hs2st1tm1.1Je,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hs2st1tm1.1Je Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-EYFP)Hze/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

 MP:0002896 abnormal bone mineralization "defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0004620 cervical vertebral fusion "the union of one or more cervical vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0006032 abnormal ureteric bud morphology "anomaly in the formation or development of the ureteric bud that with the metanephric mesenchyme gives rise to the kidneys " [smb:Susan M Bello, Mouse Genome Informatics Curator, J:57313:]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn1ctm1Kat/Cdkn1c+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008277 abnormal sternum ossification "anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958, MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hs2st1tm1.1Je/Hs2st1tm1.1Je,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Hs2st1tm1.1Je Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0010714 coloboma of the iris "congenital defect of the iris in which some part of the structure is absent" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Hs2st1tm1.2Je/Hs2st1tm1.2Je
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Jmjd6tm1.1Gbf/Jmjd6tm1.1Gbf
Genetic Background: C57BL/6-Jmjd6tm1.1Gbf

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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