ENSMUSG00000040287


Mus musculus

Features
Gene ID: ENSMUSG00000040287
  
Biological name :Stac3
  
Synonyms : Q8BZ71 / SH3 and cysteine-rich domain-containing protein 3 / Stac3
  
Possible biological names infered from orthology : Q96MF2 / SH3 and cysteine rich domain 3
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 127501686
Gene end: 127508823
  
Corresponding Affymetrix probe sets: 10366938 (MoGene1.0st)   1458087_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048148
Ensembl peptide - ENSMUSP00000124638
Ensembl peptide - ENSMUSP00000125124
NCBI entrez gene - 237611     See in Manteia.
MGI - MGI:3606571
RefSeq - XM_017313940
RefSeq - NM_177707
RefSeq - XM_006513640
RefSeq - XM_006513642
RefSeq Peptide - NP_808375
swissprot - E0CXX9
swissprot - Q8BZ71
Ensembl - ENSMUSG00000040287
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stac3ENSDARG00000098883Danio rerio
 STAC3ENSG00000185482Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stac / P97306 / src homology three (SH3) and cysteine rich domain / Q99469* / SH3 and cysteine rich domain*ENSMUSG0000003250236
Stac2 / Q8R1B0 / SH3 and cysteine-rich domain-containing protein 2 / Q6ZMT1* / SH3 and cysteine rich domain 2*ENSMUSG0000001740033


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR035736  Stac3, first SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003009 skeletal muscle contraction IEA
 biological_processGO:0007274 neuromuscular synaptic transmission IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0048741 skeletal muscle fiber development IMP
 biological_processGO:1901387 positive regulation of voltage-gated calcium channel activity IMP
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IMP
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0042383 sarcolemma IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
Show

Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001404 no spontaneous movement "failure to make any change in position or posture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001491 unresponsive to tactile stimuli "absence of reflex action normally induced by touch or pain" [J:43515, J:47439]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001506 limp posture "lack of rigidity of the carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002279 abnormal diaphragm morphology "structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cpt1cGt(XL823)Byg/Cpt1c+,Nf1tm1Tyj/Nf1+,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004136 abnormal tongue muscle morphology "anomalous structure or development of the muscular portion of the tongue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004145 abnormal muscle electrophysiology "anomaly in the function of the musculature as it relates to electrical phenomena" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004246 abnormal extensor digitorum longus morphology "any structural anomaly of penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004353 abnormal deltoid tuberosity morphology "any structural anomaly of a rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004627 abnormal trochanter morphology "any structural anomaly of the bony prominences near the upper extremity of the femur; there are two in human (greater and lesser trochanters) and three in many other mammalian species (greater, lesser and third); these normally serve as attachment points for hip and thigh muscles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0004835 abnormal miniature endplate potential "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0005162 carpoptosis "paralysis of the extensors of the wrist and fingers; most often caused by a lesion of the radial nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:81738]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0006432 abnormal costal cartilage morphology "any structural anomaly of the nonvascular, resilient, flexible connective tissue that connects the end of a true rib to the sternum or the end of a false rib with the costal cartilage above" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0009401 increased skeletal muscle fiber diameter "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hsd11b1tm1.2Tuck/Hsd11b1tm1.2Tuck
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0012055 abnormal phrenic nerve innervation pattern to diaphragm "any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm" [MGI:csmith]
Show

Allelic Composition: Stac3tm1a(KOMP)Wtsi/Stac3tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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