ENSMUSG00000040359


Mus musculus

Features
Gene ID: ENSMUSG00000040359
  
Biological name :Ufl1
  
Synonyms : Q8CCJ3 / Ufl1 / UFM1 specific ligase 1
  
Possible biological names infered from orthology : O94874
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A3
Gene start: 25248600
Gene end: 25281821
  
Corresponding Affymetrix probe sets: 10511843 (MoGene1.0st)   1429008_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042118
Ensembl peptide - ENSMUSP00000100059
NCBI entrez gene - 67490     See in Manteia.
MGI - MGI:1914740
RefSeq - XM_006538204
RefSeq - NM_026194
RefSeq - XM_006538203
RefSeq Peptide - NP_001342441
RefSeq Peptide - NP_080470
swissprot - Q8CCJ3
Ensembl - ENSMUSG00000040359
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ufl1ENSDARG00000007496Danio rerio
 UFL1ENSGALG00000015580Gallus gallus
 UFL1ENSG00000014123Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR018611  E3 UFM1-protein ligase 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010468 regulation of gene expression IMP
 biological_processGO:0031397 negative regulation of protein ubiquitination ISS
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity ISS
 biological_processGO:0032092 positive regulation of protein binding TAS
 biological_processGO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
 biological_processGO:0032880 regulation of protein localization ISO
 biological_processGO:0033146 regulation of intracellular estrogen receptor signaling pathway ISS
 biological_processGO:0034976 response to endoplasmic reticulum stress ISO
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0060252 positive regulation of glial cell proliferation IMP
 biological_processGO:0071569 protein ufmylation ISS
 biological_processGO:1902065 response to L-glutamate IMP
 biological_processGO:1990592 protein K69-linked ufmylation ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043005 neuron projection IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0071568 UFM1 transferase activity ISO


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Wdfy3tm1a(KOMP)Mbp/Wdfy3+
Genetic Background: C57BL/6N-Wdfy3tm1a(KOMP)Mbp

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Wdfy3tm1a(KOMP)Mbp/Wdfy3+
Genetic Background: C57BL/6N-Wdfy3tm1a(KOMP)Mbp

Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Wdfy3tm1a(KOMP)Mbp/Wdfy3+
Genetic Background: C57BL/6N-Wdfy3tm1a(KOMP)Mbp

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0005152 pancytopenia "reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:20450]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wdfy3tm1a(KOMP)Mbp/Wdfy3+
Genetic Background: C57BL/6N-Wdfy3tm1a(KOMP)Mbp

Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ufl1tm1c(EUCOMM)Wtsi/Ufl1tm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6N

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Wdfy3tm1a(KOMP)Mbp/Wdfy3+
Genetic Background: C57BL/6N-Wdfy3tm1a(KOMP)Mbp

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kmt5btm1a(KOMP)Wtsi/Kmt5btm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Kmt5btm1a(KOMP)Wtsi/Wtsi

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Wdfy3tm1a(KOMP)Mbp/Wdfy3+
Genetic Background: C57BL/6N-Wdfy3tm1a(KOMP)Mbp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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