ENSMUSG00000040407


Mus musculus

Features
Gene ID: ENSMUSG00000040407
  
Biological name :Akap9
  
Synonyms : Akap9 / A-kinase anchoring protein 9
  
Possible biological names infered from orthology : Q99996
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A1
Gene start: 3928054
Gene end: 4081310
  
Corresponding Affymetrix probe sets: 10519420 (MoGene1.0st)   1435769_at (Mouse Genome 430 2.0 Array)   1437082_at (Mouse Genome 430 2.0 Array)   1446237_at (Mouse Genome 430 2.0 Array)   1447912_x_at (Mouse Genome 430 2.0 Array)   1447913_x_at (Mouse Genome 430 2.0 Array)   1455151_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143327
Ensembl peptide - ENSMUSP00000117209
Ensembl peptide - ENSMUSP00000133522
Ensembl peptide - ENSMUSP00000135836
Ensembl peptide - ENSMUSP00000046129
NCBI entrez gene - 100986     See in Manteia.
MGI - MGI:2178217
RefSeq - XM_017320588
RefSeq - XM_006503521
RefSeq - XM_006503522
RefSeq - XM_006503523
RefSeq - XM_006503524
RefSeq - XM_017320586
RefSeq - XM_017320587
RefSeq - NM_194462
RefSeq - XM_006503518
RefSeq - XM_006503519
RefSeq - XM_006503520
RefSeq Peptide - NP_919444
swissprot - E9QQ10
swissprot - G3UX24
swissprot - H3BLL7
swissprot - A0A140T8S1
swissprot - A0A0G2JFW0
Ensembl - ENSMUSG00000040407
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akap9ENSDARG00000079610Danio rerio
 AKAP9ENSGALG00000040724Gallus gallus
 AKAP9ENSG00000127914Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pcnt / pericentrin / O95613*ENSMUSG0000000115117


Protein motifs (from Interpro)
Interpro ID Name
 IPR019528  Pericentrin/AKAP-450 centrosomal targeting domain
 IPR028745  A-kinase anchor protein 9/Pericentrin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007020 microtubule nucleation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007194 negative regulation of adenylate cyclase activity IEA
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0051602 response to electrical stimulus IEA
 biological_processGO:0051661 maintenance of centrosome location IEA
 biological_processGO:0060306 regulation of membrane repolarization IEA
 biological_processGO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IEA
 biological_processGO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction IEA
 biological_processGO:1901018 positive regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:1903358 regulation of Golgi organization IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005795 Golgi stack IEA
 cellular_componentGO:0005801 cis-Golgi network IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0044307 dendritic branch IEA
 cellular_componentGO:0097060 synaptic membrane IEA
 molecular_functionGO:0015459 potassium channel regulator activity IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA
 molecular_functionGO:0034237 protein kinase A regulatory subunit binding IEA
 molecular_functionGO:0044325 ion channel binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation upon Ca2+ influx through NMDA receptor
Phase 3 - rapid repolarisation
Phase 2 - plateau phase
Anchoring of the basal body to the plasma membrane
RAF/MAP kinase cascade
AURKA Activation by TPX2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr2tm1a(EUCOMM)Wtsi/Agtr2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Agtr2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agtr2tm1a(EUCOMM)Wtsi/Agtr2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Agtr2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agtr2tm1a(EUCOMM)Wtsi/Agtr2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Agtr2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0000432 abnormal head morphology "anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agtr2tm1a(EUCOMM)Wtsi/Agtr2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Agtr2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Akap9tm1b(KOMP)Wtsi/Akap9tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

Allelic Composition: Akap9mei2-5/Akap9repro12
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Akap9tm1b(KOMP)Wtsi/Akap9tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

Allelic Composition: Akap9mei2-5/Akap9repro12
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Akap9repro12/Akap9tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Agtr2tm1a(EUCOMM)Wtsi/Agtr2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Agtr2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Akap9tm1a(KOMP)Wtsi/Wtsi

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Akap9repro12/Akap9repro12
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Akap9tm1b(KOMP)Wtsi/Akap9tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

 MP:0002100 abnormal tooth morphology "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccdc80tm1Ppal/Ccdc80+
Genetic Background: Not Specified

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox10tm2(rtTA)Weg/Sox10+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Akap9repro12/Akap9repro12
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Akap9repro12/Akap9repro12
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004109 abnormal Sertoli cell development "anomalous differentiation of cells that support germ cell differentiation in males" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Akap9tm1b(KOMP)Wtsi/Akap9tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

 MP:0004509 abnormal pelvic girdle bone morphology "any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Akap9tm1a(KOMP)Wtsi/Wtsi

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akap9repro12/Akap9repro12
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akap9repro12/Akap9repro12
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Akap9tm1b(KOMP)Wtsi/Akap9tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

Allelic Composition: Akap9mei2-5/Akap9repro12
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Akap9repro12/Akap9tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtr2tm1a(EUCOMM)Wtsi/Agtr2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Agtr2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtr2tm1a(EUCOMM)Wtsi/Agtr2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Agtr2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Agtr2tm1a(EUCOMM)Wtsi/Agtr2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Agtr2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Akap9tm1b(KOMP)Wtsi/Akap9tm1b(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N * FVB/N

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ptpn11tm1Bgn/Ptpn11+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1a(EUCOMM)Wtsi/Agtr2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Agtr2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010087 increased circulating fructosamine level "increase in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1a(EUCOMM)Wtsi/Agtr2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Agtr2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010088 decreased circulating fructosamine level "decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr2tm1a(EUCOMM)Wtsi/Agtr2tm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Agtr2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Akap9tm1a(KOMP)Wtsi/Akap9+
Genetic Background: involves: C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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