MP:0000111 | cleft palate | "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Pax6-cre,GFP)2Pgr/0 Genetic Background: involves: 129
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MP:0000259 | abnormal vascular development | "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509] |
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Pax6-cre,GFP)2Pgr/0 Genetic Background: involves: 129
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MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Pax6-cre,GFP)2Pgr/0 Genetic Background: involves: 129
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MP:0000273 | overriding aorta | "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0000433 | microcephaly | "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Pax6-cre,GFP)2Pgr/0 Genetic Background: involves: 129
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MP:0000522 | cysts in kidney cortex | "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0000562 | polydactyly | "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo Genetic Background: B6.129S1-Tnftm1Ljo
Allelic Composition: Pcntm239Asp/Pcntm239Asp,Tg(mI56i-lacZ)1Mekk/0 Genetic Background: involves: C57BL/6J * FVB/N
Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0000564 | syndactyly | "any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0000774 | reduced brain size | "smaller appearance of the brain" [J:35802] |
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N
Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0000788 | abnormal cerebral cortex morphology | "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857] |
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo Genetic Background: B6.129S1-Tnftm1Ljo
Allelic Composition: Pcntm239Asp/Pcntm239Asp,Tg(mI56i-lacZ)1Mekk/0 Genetic Background: involves: C57BL/6J * FVB/N
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MP:0000807 | abnormal hippocampus morphology | "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0000913 | abnormal brain development | "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840] |
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Pax6-cre,GFP)2Pgr/0 Genetic Background: involves: 129
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MP:0000951 | sporadic seizures | "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo Genetic Background: B6.129S1-Tnftm1Ljo
Allelic Composition: Pcntm239Asp/Pcnt+,Tg(mI56i-lacZ)1Mekk/0 Genetic Background: involves: C57BL/6J * FVB/N
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MP:0001177 | atelectasis | "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0001178 | pulmonary hypoplasia | "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0001293 | anophthalmia | "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0001297 | microphthalmia | "reduced average size of the eyes" [J:18048] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0001915 | intracranial hemorrhage | "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0002081 | perinatal lethality | "death anytime between E18.5 and postnatal day 1 " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo Genetic Background: B6.129S1-Tnftm1Ljo
Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tnftm1Ljo/Tnftm1Ljo Genetic Background: B6.129S1-Tnftm1Ljo
Allelic Composition: Pcntm239Asp/Pcnt+,Tg(mI56i-lacZ)1Mekk/0 Genetic Background: involves: C57BL/6J * FVB/N
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MP:0002092 | abnormal eye morphology | "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Pax6-cre,GFP)2Pgr/0 Genetic Background: involves: 129
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MP:0002135 | abnormal kidney morphology | "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Vegfatm2Gne/Vegfatm2Gne,Tg(Pax6-cre,GFP)2Pgr/0 Genetic Background: involves: 129
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MP:0002192 | hydrops fetalis | "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0002741 | small olfactory bulb | "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871] |
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N
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MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0003935 | abnormal craniofacial development | "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N
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MP:0004017 | duplex kidney | "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0004261 | abnormal embryonic neuroepithelium morphology | "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0004948 | abnormal neuronal precursor proliferation | "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N
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MP:0006009 | abnormal neuronal migration | "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N
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MP:0006042 | increased apoptosis | "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N
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MP:0006045 | mitral valve insufficiency | "the mitral valve does not close tightly enough to prevent leakage" [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0006047 | aortic valve insufficiency | "the aortic valve does not close tightly enough to prevent leakage. " [smb:Susan M Bello, Mouse Genome Informatics Curator, RGD:Rat Genome Database submission] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0006113 | abnormal heart septum morphology | "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0006254 | thin cerebral cortex | "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683] |
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N
Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0008441 | thin cortical plate | "reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0008458 | abnormal cortical ventricular zone morphology | "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0008772 | enlarged heart ventricle | "increased average size of the heart ventricles compared to the average for a particular population" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0009743 | preaxial polydactyly | "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433] |
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Allelic Composition: Gad1tm1.1Tama/Gad1+,Pcntm239Asp/Pcntm239Asp Genetic Background: involves: C57BL/6 * C57BL/6J * CBA * FVB/N
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MP:0009760 | abnormal mitotic spindle | "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0009937 | abnormal neuron differentiation | "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0010403 | atrial septal defect | "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0010412 | atrioventricular septal defect | "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0010865 | prenatal growth retardation | "slow or limited development during the prenatal period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0010993 | decreased surfactant secretion | "decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0011380 | enlarged brain ventricle | "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0011495 | abnormal head shape | "any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0011682 | renal glomerulus cysts | "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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MP:0012285 | misaligned sternebrae | "abnormal alignment of the sternebrae along the ventral midline" [MGI:anna] |
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Allelic Composition: PcntGt(RRU388)Byg/PcntGt(RRU388)Byg Genetic Background: B6.129P2-PcntGt(RRU388)Byg
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