Manteia - Molecule gene

ENSMUSG00000040432

Mus musculus

Features

Gene ID:	ENSMUSG00000040432

Biological name :	Ltb4r2

Synonyms :	Leukotriene B4 receptor 2 / Ltb4r2 / Q9JJL9

Possible biological names infered from orthology :	Q9NPC1

Species:	Mus musculus

Chr. number:	14
Strand:	1
Band:	C3
Gene start:	55761428
Gene end:	55765138

Corresponding Affymetrix probe sets:	10415388 (MoGene1.0st) 1450807_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000048358 NCBI entrez gene - 57260 See in Manteia. MGI - MGI:1888501 RefSeq - NM_020490 RefSeq - XM_006519326 RefSeq Peptide - NP_065236 swissprot - Q9JJL9 Ensembl - ENSMUSG00000040432

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
LTB4R2	ENSG00000213906	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ltb4r1 / O88855 / Leukotriene B4 receptor 1 / LTB4R* / Q15722* / leukotriene B4 receptor*	ENSMUSG00000046908	28

Protein motifs (from Interpro)

Interpro ID	Name
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR003981	Leukotriene B4 receptor
IPR003982	Leukotriene B4 type 2 receptor
IPR017452	GPCR, rhodopsin-like, 7TM

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007165	signal transduction	IDA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	IBA
biological_process	GO:0007218	neuropeptide signaling pathway	IBA
biological_process	GO:0051546	keratinocyte migration	IDA
biological_process	GO:0061737	leukotriene signaling pathway	IEA
cellular_component	GO:0005654	nucleoplasm	IEA
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0016020	membrane	IDA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0001632	leukotriene B4 receptor activity	IDA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0004974	leukotriene receptor activity	IEA
molecular_function	GO:0008528	G-protein coupled peptide receptor activity	IBA

Pathways (from Reactome)

Pathway description

Leukotriene receptors

G alpha (q) signalling events

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001785	edema	"an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]	Show Allelic Composition: Pla2g5^tm1Jarm/Pla2g5^tm1Jarm Genetic Background: B6.129-Pla2g5^tm1Jarm
MP:0002423	abnormal mast cell physiology	"anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gt(ROSA)26Sor^tm1Jus/Gt(ROSA)26Sor⁺,Tg(MMTV-cre)4Mam/0 Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N
MP:0003436	resistance to induced arthritis	"less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]	Show Allelic Composition: Kat8^tm1.1Avo/Kat8^tm1.1Avo Genetic Background: involves: BALB/cJ * C57BL/6 Allelic Composition: Ltb4r1/Ltb4r2^tm2Bodd/Ltb4r2⁺ Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 Allelic Composition: Ltb4r2^tm1Bodd/Ltb4r2^tm1Bodd Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0005597	decreased susceptibility to type I hypersensitivity reaction	"less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Pla2g5^tm1Jarm/Pla2g5^tm1Jarm Genetic Background: B6.129-Pla2g5^tm1Jarm
MP:0008720	impaired neutrophil migration	"defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kat8^tm1.1Avo/Kat8^tm1.1Avo Genetic Background: involves: BALB/cJ * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr