ENSMUSG00000046908


Mus musculus

Features
Gene ID: ENSMUSG00000046908
  
Biological name :Ltb4r1
  
Synonyms : Leukotriene B4 receptor 1 / Ltb4r1 / O88855
  
Possible biological names infered from orthology : leukotriene B4 receptor / LTB4R / Q15722
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C3
Gene start: 55765962
Gene end: 55768494
  
Corresponding Affymetrix probe sets: 10415392 (MoGene1.0st)   1420407_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051368
NCBI entrez gene - 16995     See in Manteia.
MGI - MGI:1309472
RefSeq - XM_006518666
RefSeq - NM_008519
RefSeq Peptide - NP_032545
swissprot - O88855
swissprot - A7VJD3
Ensembl - ENSMUSG00000046908
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ltb4rENSDARG00000032631Danio rerio
 LTB4RENSGALG00000032348Gallus gallus
 LTB4RENSG00000213903Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ltb4r2 / Q9JJL9 / Leukotriene B4 receptor 2 / Q9NPC1*ENSMUSG0000004043229


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR003981  Leukotriene B4 receptor
 IPR003983  Leukotriene B4 type 1 receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0061737 leukotriene signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0001632 leukotriene B4 receptor activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004974 leukotriene receptor activity IEA
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IBA


Pathways (from Reactome)
Pathway description
Leukotriene receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltb4r1tm1Bodd/Ltb4r1tm1Bodd
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002462 abnormal granulocyte physiology "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1Jus/Gt(ROSA)26Sor+,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ltb4r1tm1Bodd/Ltb4r1tm1Bodd
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Ltb4r1tm1Bodd/Ltb4r1tm1Bodd
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Kat8tm1.1Avo/Kat8tm1.1Avo
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Ltb4r1/Ltb4r2tm2Bodd/Ltb4r1+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Ltb4r1tm1Bodd/Ltb4r1tm1Bodd
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Ltb4r1tm1Bodd/Ltb4r1tm1Bodd
Genetic Background: either: (involves: 129S4/SvJaeSor * BALB/c ) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Ltb4r1tm1Bodd/Ltb4r1tm1Bodd
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Ltb4r1tm1Adl/Ltb4r1tm1Adl
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005351 decreased susceptibility to autoimmune disorders "reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tor1atm1Wtd/Tor1atm2Wtd
Genetic Background: involves: 129S1/Sv

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kat8tm1.1Avo/Kat8tm1.1Avo
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Ltb4r1tm1Adl/Ltb4r1tm1Adl
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ltb4r1tm1Bodd/Ltb4r1tm1Bodd
Genetic Background: either: (involves: 129S4/SvJaeSor * BALB/c ) or (involves: 129S4/SvJaeSor * C57BL/6)

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ltb4r1tm1Adl/Ltb4r1tm1Adl
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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