ENSMUSG00000040653


Mus musculus

Features
Gene ID: ENSMUSG00000040653
  
Biological name :Ppp1r14c
  
Synonyms : Ppp1r14c / protein phosphatase 1, regulatory (inhibitor) subunit 14c / Q8R4S0
  
Possible biological names infered from orthology : Q8TAE6
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A1
Gene start: 3366057
Gene end: 3464975
  
Corresponding Affymetrix probe sets: 10367697 (MoGene1.0st)   1417701_at (Mouse Genome 430 2.0 Array)   1430286_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149688
Ensembl peptide - ENSMUSP00000045110
NCBI entrez gene - 76142     See in Manteia.
MGI - MGI:1923392
RefSeq - NM_133485
RefSeq - XM_006512489
RefSeq Peptide - NP_597844
swissprot - A0A1L1SRZ2
swissprot - Q8R4S0
Ensembl - ENSMUSG00000040653
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r14cENSDARG00000077341Danio rerio
 PPP1R14CENSGALG00000041575Gallus gallus
 Q8TAE6ENSG00000198729Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q62084 / Ppp1r14b / Protein phosphatase 1 regulatory subunit 14B / Q96C90* / protein phosphatase 1 regulatory inhibitor subunit 14B*ENSMUSG0000005661245
4933415F23Rik / RIKEN cDNA 4933415F23 geneENSMUSG0000007373041
Q91VC7 / Ppp1r14a / Protein phosphatase 1 regulatory subunit 14A / Q96A00* / protein phosphatase 1 regulatory inhibitor subunit 14A*ENSMUSG0000003716630
Q7TT52 / Ppp1r14d / Protein phosphatase 1 regulatory subunit 14D / Q9NXH3* / protein phosphatase 1 regulatory inhibitor subunit 14D*ENSMUSG0000002731715


Protein motifs (from Interpro)
Interpro ID Name
 IPR008025  CPI-17
 IPR036658  CPI-17 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0042325 regulation of phosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane ISO
 molecular_functionGO:0004864 protein phosphatase inhibitor activity IEA
 molecular_functionGO:0004865 protein serine/threonine phosphatase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001981 enhanced chemically-elicited antinociception "greater than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Clpstm1Lowe/Clpstm1Lowe
Genetic Background: involves: 129S6/SvEvTac

 MP:0009711 abnormal conditioned place preference behavior "anomaly in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clpstm1Lowe/Clpstm1Lowe
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ppp1r14ctm1Uhl/Ppp1r14c+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009748 abnormal behavioral response to addictive substance "any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clpstm1Lowe/Clpstm1Lowe
Genetic Background: involves: 129S6/SvEvTac

 MP:0009753 enhanced behavioral response to morphine "increased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clpstm1Lowe/Clpstm1Lowe
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ppp1r14ctm1Uhl/Ppp1r14c+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Clpstm1Lowe/Clpstm1Lowe
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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