ENSMUSG00000040681


Mus musculus

Features
Gene ID: ENSMUSG00000040681
  
Biological name :Hmgn1
  
Synonyms : Hmgn1 / Non-histone chromosomal protein HMG-14 / P18608
  
Possible biological names infered from orthology : high mobility group nucleosome binding domain 1 / P05114
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C4
Gene start: 96120618
Gene end: 96127729
  
Corresponding Affymetrix probe sets: 10441161 (MoGene1.0st)   1422495_a_at (Mouse Genome 430 2.0 Array)   1422496_at (Mouse Genome 430 2.0 Array)   1438940_x_at (Mouse Genome 430 2.0 Array)   1455897_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122427
Ensembl peptide - ENSMUSP00000061012
NCBI entrez gene - 15312     See in Manteia.
MGI - MGI:96120
RefSeq - NM_008251
RefSeq Peptide - NP_032277
swissprot - D3Z607
swissprot - P18608
Ensembl - ENSMUSG00000040681
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HMGN1ENSGALG00000016067Gallus gallus
 HMGN1ENSG00000205581Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000079  High mobility group protein HMGN


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000720 pyrimidine dimer repair by nucleotide-excision repair IMP
 biological_processGO:0006283 transcription-coupled nucleotide-excision repair IMP
 biological_processGO:0006325 chromatin organization IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0010224 response to UV-B IMP
 biological_processGO:0010225 response to UV-C IDA
 biological_processGO:0040034 regulation of development, heterochronic IGI
 biological_processGO:0048597 post-embryonic camera-type eye morphogenesis IMP
 biological_processGO:0050678 regulation of epithelial cell proliferation IMP
 biological_processGO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity IMP
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031492 nucleosomal DNA binding IEA


Pathways (from Reactome)
Pathway description
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001203 skin irradiation sensitivity "increased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage" [J:65162]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hmgn1tm1Mbus/Hmgn1+
Genetic Background: involves: 129X1/SvJ

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hmgn1tm1Mbus/Hmgn1+
Genetic Background: involves: 129X1/SvJ

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002050 pheochromocytoma "a benign neoplasm derived from adrenal medullary cells; usually associated with hypertension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002947 hemangioma "proliferation of blood vessels leading to a mass that resembles a neoplasm" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87544]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004500 increased incidence of ionizing radiation-induced tumors "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008410 increased cellular sensitivity to ultraviolet irradiation "greater incidence of cell death following exposure to ultraviolet irradiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Hmgn1tm1Mbus/Hmgn1+
Genetic Background: either: (involves: 129/Sv * 129X1/SvJ) or (involves: 129/Sv * 129X1/SvJ * C57BL/6)

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Notch2tm2Grid/Notch2tm2Grid
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr