ENSMUSG00000040913


Mus musculus

Features
Gene ID: ENSMUSG00000040913
  
Biological name :Fbxw4
  
Synonyms : F-box/WD repeat-containing protein 4 / Fbxw4 / Q9JMJ2
  
Possible biological names infered from orthology : F-box and WD repeat domain containing 4 / P57775
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 45578254
Gene end: 45660312
  
Corresponding Affymetrix probe sets: 10468059 (MoGene1.0st)   1417226_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036505
Ensembl peptide - ENSMUSP00000125641
Ensembl peptide - ENSMUSP00000125136
Ensembl peptide - ENSMUSP00000124998
Ensembl peptide - ENSMUSP00000124675
Ensembl peptide - ENSMUSP00000124604
Ensembl peptide - ENSMUSP00000124084
NCBI entrez gene - 30838     See in Manteia.
MGI - MGI:1354698
RefSeq - XM_011247261
RefSeq - NM_013907
RefSeq - XM_006527131
RefSeq - XM_011247258
RefSeq - XM_011247259
RefSeq Peptide - NP_038935
swissprot - E0CZ74
swissprot - Q9JMJ2
swissprot - E0CXZ3
swissprot - E0CXV9
swissprot - E0CXP5
swissprot - E0CYL5
swissprot - E0CX21
Ensembl - ENSMUSG00000040913
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbxw4ENSDARG00000033551Danio rerio
 FBXW4ENSGALG00000043428Gallus gallus
 FBXW4ENSG00000107829Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR001810  F-box domain
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR036047  F-box-like domain superfamily
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002053 positive regulation of mesenchymal cell proliferation IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
 biological_processGO:0042733 embryonic digit morphogenesis IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060173 limb development IMP
 cellular_componentGO:0019005 SCF ubiquitin ligase complex IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000561 adactyly "missing all digits; usually refered to as a congenital condition" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
Show

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

 MP:0000565 oligodactyly "congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Fbxw4Dac-2J/Fbxw4Dac-2J
Genetic Background: CBy.MRL-Fbxw4Dac-2J/J

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

Allelic Composition: Fbxw4Dac/Fbxw4+,mdac/mdac
Genetic Background: involves: SM/Ckc * BALB/cByJ

 MP:0001676 abnormal apical ectodermal ridge "malformation of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
Show

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

Allelic Composition: Fbxw4Dac/Fbxw4+,mdac/mdac
Genetic Background: involves: SM/Ckc * BALB/cByJ

 MP:0001677 absent apical ectodermal ridge "missing the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [J:54637]
Show

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

 MP:0001679 thin apical ectodermal ridge "decrease in the thickness of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme" [MGI:tc]
Show

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

Allelic Composition: Fbxw4Dac/Fbxw4+,mdac/mdac
Genetic Background: involves: SM/Ckc * BALB/cByJ

 MP:0004576 abnormal foot plate morphology "any structural anomaly of the distal elements of the developing limb of vertebrates that will give rise to the pedal appendages (e.g. hand, foot, paw)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

 MP:0005109 abnormal talus morphology "malformation of the bone that articlulates with the tibia and fibula" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

 MP:0005230 ectrodactyly "absence of the middle rays, i.e., the central digits of the paws; usually associated with cleft paws and may also include syndactyly or aplasia of remaining digits" [OMIM:Online Mendelian Inheritance in Man]
Show

Allelic Composition: Fbxw4Dac/Fbxw4Dac,mdac/mdac
Genetic Background: involves: SM/Ckc

Allelic Composition: Fbxw4Dac-2J/Fbxw4+,mdac/mdac
Genetic Background: CBy.MRL-Fbxw4Dac-2J/J

Allelic Composition: Fbxw4Dac/Fbxw4+,mdac/mdac
Genetic Background: involves: SM/Ckc * BALB/cByJ

 MP:0006279 abnormal limb development "anomaly in the formation of the limbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

 MP:0006280 abnormal digit development "anomaly in the formation of the digits" [J:70592, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

Allelic Composition: Fbxw4Dac/Fbxw4+,mdac/mdac
Genetic Background: involves: SM/Ckc * BALB/cByJ

 MP:0008730 fused phalanges "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fbxw4Dac/Fbxw4+,mdac/mdac
Genetic Background: involves: SM/Ckc * BALB/cByJ

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Sharpincpdm-Dem/Sharpincpdm-Dem
Genetic Background: CBy.OcB3-Sharpincpdm-Dem

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: F9tm1Ver/F9tm1Ver
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fbxw4Dac/Fbxw4Dac,mdac/mdac
Genetic Background: involves: SM/Ckc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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