Manteia

ENSMUSG00000041355

Mus musculus

Features

Gene ID:	ENSMUSG00000041355

Biological name :	Ssr2

Synonyms :	Q9CPW5 / signal sequence receptor, beta / Ssr2

Possible biological names infered from orthology :	P43308 / signal sequence receptor subunit 2

Species:	Mus musculus

Chr. number:	3
Strand:	1
Band:	F1
Gene start:	88575876
Gene end:	88588419

Corresponding Affymetrix probe sets:	10493259 (MoGene1.0st) 1449930_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000141325 Ensembl peptide - ENSMUSP00000141922 Ensembl peptide - ENSMUSP00000141591 Ensembl peptide - ENSMUSP00000141471 Ensembl peptide - ENSMUSP00000141441 Ensembl peptide - ENSMUSP00000141389 Ensembl peptide - ENSMUSP00000045456 NCBI entrez gene - 66256 See in Manteia. MGI - MGI:1913506 RefSeq - XM_006501878 RefSeq - NM_001356317 RefSeq - NM_001356318 RefSeq - NM_025448 RefSeq Peptide - NP_079724 RefSeq Peptide - NP_001343246 RefSeq Peptide - NP_001343247 swissprot - A0A0A6YWA8 swissprot - A0A0A6YW45 swissprot - A0A0A6YWL0 swissprot - A0A0A6YVZ1 swissprot - Q9CPW5 swissprot - A0A0A6YXB7 Ensembl - ENSMUSG00000041355

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ssr2	ENSDARG00000005230	Danio rerio
SSR2	ENSGALG00000000764	Gallus gallus
SSR2	ENSG00000163479	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR008856	Translocon-associated protein subunit beta
IPR013783	Immunoglobulin-like fold

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006613	cotranslational protein targeting to membrane	IBA
cellular_component	GO:0005783	endoplasmic reticulum	IBA
cellular_component	GO:0005789	endoplasmic reticulum membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0003674	molecular_function	ND

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000161	scoliosis	"lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0000282	abnormal atrial septum morphology	"abnormality in the wall between the atria of the heart, usually incomplete closure " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0000284	double outlet right ventricle	"both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0000602	enlarged sinusoidal spaces	"larger than normal sized cavities in the liver " [J:23170]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0000703	abnormal thymus morphology	"anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0000825	dilated lateral ventricles	"increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0001015	small superior cervical ganglion	"reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck" [J:23882]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0001330	abnormal optic nerve morphology	"malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0001916	intracerebral hemorrhage	"bleeding within the cerebrum" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0002279	abnormal diaphragm morphology	"structural defect in the thin musculomebraneous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0002633	persistent truncus arteriosis	"complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0003686	abnormal eye muscle morphology	"malformation of the muscles of the eye" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0003827	abnormal Wolffian duct morphology	"malformation of the transient embryonic tubes that empty into the cloca and degenerate in the male " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0004057	thin myocardial compact layer	"reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0004201	fetal growth retardation	"slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0004268	abnormal optic stalk morphology	"any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain" [ISBN:0-914294-08-3 "Gray s Anatomy"]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0004269	abnormal optic cup morphology	"any structural anomaly of double walled stuctured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0004463	basisphenoid bone foramen	"the presence of one or more holes in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0004613	fusion of vertebral arches	"improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0005244	hemopericardium	"bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0008536	enlarged third ventricle	"increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0009770	abnormal optic chiasm morphology	"an anomaly in the flattened quadrangular body that is the point of crossing of the fibers of the optic nerves" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0009913	abnormal hyoid bone greater horn morphology	"any structural anomaly of the larger and more lateral of the paired processes on either side of the hyoid bone" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0010418	perimembraneous ventricular septal defect	"abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0010420	muscular ventricular septal defect	"abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0010490	abnormal inferior vena cava valve morphology	"any structural anomaly of the semicircular fold of endocardium located on the right atrium at the point of attachment of the inferior vena cava" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0010589	common truncal valve	"a single outflow tract valve that opens into the truncus arteriosus that is frequently present in cases of truncus arteriosus septation defects" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0010592	abnormal atrioventricular septum morphology	"any structural anomaly of the wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0010602	abnormal pulmonary valve cusp morphology	"any structural anomaly of the three fibrous triangular components and associated flap of the pulmonary valve" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0011659	interrupted aortic arch, type b	"complete discontinuation/blockage between the ascending and descending aorta with the interruption located between second carotid artery and ipsilateral subclavian artery" [MGI:csmith]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0013815	abnormal digastric muscle morphology		Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0013836	abnormal hypoglossal nerve topology	"abnormal position of the hypoglossal nerve " [MGI:csmith]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0013848	subcutaneous edema	"accumulation of watery or serous fluid in the subcutaneous region below the skin" [MGI:csmith]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0013875	trigeminal neuroma		Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0013876	absent ductus venosus valve	"absence of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0013877	abnormal ductus venosus valve morphology	"any structural anomaly of the valve present on the right side of the ductus venosus at the site of the junction with the inferior vena cava" [PMID:5438957]	Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0013967	abnormal infrahyoid muscle connection		Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0013969	reduced sympathetic cervical ganglion size		Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0013973	abnormal hepatic vein connection		Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi
MP:0014021	heterochrony		Show Allelic Composition: Smg9^{tm1b(EUCOMM)Wtsi}/Smg9^{tm1b(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Smg9^{tm1b(EUCOMM)Wtsi}/Wtsi

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr