ENSMUSG00000041359


Mus musculus

Features
Gene ID: ENSMUSG00000041359
  
Biological name :Tcl1
  
Synonyms : P56280 / T cell lymphoma breakpoint 1 / Tcl1
  
Possible biological names infered from orthology : P56279 / T cell leukemia/lymphoma 1A / TCL1A
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: E
Gene start: 105216750
Gene end: 105222793
  
Corresponding Affymetrix probe sets: 10402514 (MoGene1.0st)   1422458_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134811
Ensembl peptide - ENSMUSP00000036066
Ensembl peptide - ENSMUSP00000098632
Ensembl peptide - ENSMUSP00000134903
Ensembl peptide - ENSMUSP00000135069
NCBI entrez gene - 21432     See in Manteia.
MGI - MGI:1097166
RefSeq - NM_001289468
RefSeq - NM_001309484
RefSeq - NM_001309485
RefSeq - NM_009337
RefSeq Peptide - NP_033363
RefSeq Peptide - NP_001276397
RefSeq Peptide - NP_001296413
RefSeq Peptide - NP_001296414
swissprot - H3BJA0
swissprot - H3BJ18
swissprot - P56280
swissprot - Q3UES7
swissprot - H3BJP6
Ensembl - ENSMUSG00000041359
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000038681Gallus gallus
 TCL1AENSG00000100721Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mtcp1 / Q60945 / Protein p13 MTCP-1 / P56278* / mature T cell proliferation 1*ENSMUSG0000003120021
Tcl1b2 / P56841 / T cell leukemia/lymphoma 1B, 2 / TCL1B* / O95988* / T cell leukemia/lymphoma 1B*ENSMUSG0000006086313
Tcl1b3 / P56842 / T cell leukemia/lymphoma 1B, 3 / TCL1B* / O95988* / T cell leukemia/lymphoma 1B*ENSMUSG0000006894013
Tcl1b4 / P56844 / Protein TCL1B4 / TCL1B* / O95988* / T cell leukemia/lymphoma 1B*ENSMUSG0000007900713


Protein motifs (from Interpro)
Interpro ID Name
 IPR004832  TCL1/MTCP1
 IPR036672  TCL1/MTCP1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010918 positive regulation of mitochondrial membrane potential ISO
 biological_processGO:0019827 stem cell population maintenance IMP
 biological_processGO:0032461 positive regulation of protein oligomerization ISO
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation ISO
 biological_processGO:0043066 negative regulation of apoptotic process ISO
 biological_processGO:0070207 protein homotrimerization ISO
 biological_processGO:0071356 cellular response to tumor necrosis factor ISO
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity ISO
 biological_processGO:2000036 regulation of stem cell population maintenance IGI
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045120 pronucleus IDA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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