ENSMUSG00000041440


Mus musculus

Features
Gene ID: ENSMUSG00000041440
  
Biological name :Gk5
  
Synonyms : Gk5 / Putative glycerol kinase 5 / Q8BX05
  
Possible biological names infered from orthology : glycerol kinase 5 (putative) / Q6ZS86
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.3
Gene start: 96119362
Gene end: 96184608
  
Corresponding Affymetrix probe sets: 10587988 (MoGene1.0st)   1436210_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000082313
Ensembl peptide - ENSMUSP00000112717
Ensembl peptide - ENSMUSP00000123594
NCBI entrez gene - 235533     See in Manteia.
MGI - MGI:2443336
RefSeq - XM_006511134
RefSeq - NM_177352
RefSeq - XM_006511131
RefSeq - XM_006511132
RefSeq - XM_006511133
RefSeq Peptide - NP_796326
swissprot - Q8BX05
swissprot - D6RCU4
Ensembl - ENSMUSG00000041440
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gk5ENSDARG00000062864Danio rerio
 GK5ENSGALG00000002729Gallus gallus
 GK5ENSG00000175066Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gk / Q64516 / Mus musculus glycerol kinase (Gk), transcript variant 5, mRNA. / GK3P* / P32189* / Q14409* / glycerol kinase* / glycerol kinase 3 pseudogene*ENSMUSG0000002505930
Gykl1ENSMUSG0000005362429
Gk2 / Q9WU65 / Glycerol kinase 2 / Q14410*ENSMUSG0000005055329


Protein motifs (from Interpro)
Interpro ID Name
 IPR000577  Carbohydrate kinase, FGGY
 IPR018483  Carbohydrate kinase, FGGY, conserved site
 IPR018484  Carbohydrate kinase, FGGY, N-terminal
 IPR018485  Carbohydrate kinase, FGGY, C-terminal
 IPR037444  Putative glycerol kinase 5, FGGY


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006071 glycerol metabolic process IBA
 biological_processGO:0006641 triglyceride metabolic process IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019563 glycerol catabolic process IEA
 biological_processGO:0046167 glycerol-3-phosphate biosynthetic process IBA
 cellular_componentGO:0005739 mitochondrion IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004370 glycerol kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016773 phosphotransferase activity, alcohol group as acceptor IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000383 abnormal hair follicle orientation "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gk5m2Btlr/Gk5m2Btlr
Genetic Background: C57BL/6J-Gk5m2Btlr

Allelic Composition: Gk5m3Btlr/Gk5m3Btlr
Genetic Background: C57BL/6J-Gk5m3Btlr

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0002992 abnormal sebaceous lipid secretion "abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin" [smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Gk5m2Btlr/Gk5m2Btlr
Genetic Background: C57BL/6J-Gk5m2Btlr

Allelic Composition: Gk5m3Btlr/Gk5m3Btlr
Genetic Background: C57BL/6J-Gk5m3Btlr

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0008858 abnormal hair cycle anagen phase "anomaly in the growth phase of the hair cycle" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0008859 abnormal hair cycle catagen phase "anomaly in the phase of the hair growth cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored hair is produced" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0008860 abnormal hair cycle telogen phase "anomaly in the resting or quiescent phase of the hair growth cycle which follows cessation of proliferation (catagen) and preceeds hair loss" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0009131 decreased white fat cell number "reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

 MP:0012232 abnormal ceramide level 
Show

Allelic Composition: Grptm1Jfb/Grptm1Jfb
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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