ENSMUSG00000025059


Mus musculus

Features
Gene ID: ENSMUSG00000025059
  
Biological name :Gk
  
Synonyms : Gk / Mus musculus glycerol kinase (Gk), transcript variant 5, mRNA. / Q64516
  
Possible biological names infered from orthology : GK3P / glycerol kinase / glycerol kinase 3 pseudogene / P32189 / Q14409
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: C1
Gene start: 85701937
Gene end: 85776819
  
Corresponding Affymetrix probe sets: 10605571 (MoGene1.0st)   1422703_at (Mouse Genome 430 2.0 Array)   1422704_at (Mouse Genome 430 2.0 Array)   1445242_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026039
Ensembl peptide - ENSMUSP00000109611
Ensembl peptide - ENSMUSP00000119564
Ensembl peptide - ENSMUSP00000120754
NCBI entrez gene - 14933     See in Manteia.
MGI - MGI:106594
RefSeq - XM_017318386
RefSeq - NM_001294138
RefSeq - NM_001294140
RefSeq - NM_001331046
RefSeq - NM_008194
RefSeq - NM_212444
RefSeq - XM_006527829
RefSeq - XM_006527831
RefSeq - XM_006527833
RefSeq Peptide - NP_001281069
RefSeq Peptide - NP_001317975
RefSeq Peptide - NP_997609
RefSeq Peptide - NP_032220
RefSeq Peptide - NP_001281067
swissprot - B1ASZ3
swissprot - Q64516
Ensembl - ENSMUSG00000025059
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GK3PENSDARG00000053456Danio rerio
 ENSGALG00000016285Gallus gallus
 GKENSG00000198814Homo sapiens
 GK3PENSG00000229894Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gk2 / Q9WU65 / Glycerol kinase 2 / Q14410*ENSMUSG0000005055382
Gykl1ENSMUSG0000005362481
Gk5 / Q8BX05 / Putative glycerol kinase 5 / Q6ZS86* / glycerol kinase 5 (putative)*ENSMUSG0000004144028


Protein motifs (from Interpro)
Interpro ID Name
 IPR000577  Carbohydrate kinase, FGGY
 IPR005999  Glycerol kinase
 IPR018483  Carbohydrate kinase, FGGY, conserved site
 IPR018484  Carbohydrate kinase, FGGY, N-terminal
 IPR018485  Carbohydrate kinase, FGGY, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006071 glycerol metabolic process IMP
 biological_processGO:0006072 glycerol-3-phosphate metabolic process IEA
 biological_processGO:0006641 triglyceride metabolic process IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019217 regulation of fatty acid metabolic process IMP
 biological_processGO:0019563 glycerol catabolic process IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0046167 glycerol-3-phosphate biosynthetic process IBA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004370 glycerol kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016773 phosphotransferase activity, alcohol group as acceptor IEA


Pathways (from Reactome)
Pathway description
Triglyceride biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp3tm1Mak/Casp3tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: B6.Cg-Casp3tm1Mak Tg(TcrLCMV)327Sdz

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Casp3tm1Mak/Casp3tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: B6.Cg-Casp3tm1Mak Tg(TcrLCMV)327Sdz

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Casp3tm1Mak/Casp3tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: B6.Cg-Casp3tm1Mak Tg(TcrLCMV)327Sdz

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp3tm1Mak/Casp3tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: B6.Cg-Casp3tm1Mak Tg(TcrLCMV)327Sdz

 MP:0001746 abnormal pituitary secretion "altered ability of the pituitary to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Casp3tm1Mak/Casp3tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: B6.Cg-Casp3tm1Mak Tg(TcrLCMV)327Sdz

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Casp3tm1Mak/Casp3tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: B6.Cg-Casp3tm1Mak Tg(TcrLCMV)327Sdz

 MP:0003441 increased glycerol level "higher than normal concentration of glycerol" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp3tm1Mak/Casp3tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: B6.Cg-Casp3tm1Mak Tg(TcrLCMV)327Sdz

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp3tm1Mak/Casp3tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: B6.Cg-Casp3tm1Mak Tg(TcrLCMV)327Sdz

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Casp3tm1Mak/Casp3tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: B6.Cg-Casp3tm1Mak Tg(TcrLCMV)327Sdz

 MP:0005282 decreased fatty acid level "less than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nxf1Mvb1/Nxf1Mvb1,Usp14ax-J/Usp14ax-J
Genetic Background: involves: C57BL/6

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nxf1Mvb1/Nxf1Mvb1,Usp14ax-J/Usp14ax-J
Genetic Background: involves: C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Casp3tm1Mak/Casp3tm1Mak,Tg(TcrLCMV)327Sdz/0
Genetic Background: B6.Cg-Casp3tm1Mak Tg(TcrLCMV)327Sdz

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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