ENSMUSG00000041560


Mus musculus

Features
Gene ID: ENSMUSG00000041560
  
Biological name :Nop53
  
Synonyms : Nop53 / Q8BK35 / Ribosome biosis protein NOP53
  
Possible biological names infered from orthology : NOP53 ribosome biogenesis factor / Q9NZM5
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A2
Gene start: 15936183
Gene end: 15946074
  
Corresponding Affymetrix probe sets: 10560181 (MoGene1.0st)   1423803_s_at (Mouse Genome 430 2.0 Array)   1451121_a_at (Mouse Genome 430 2.0 Array)   1452409_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043981
NCBI entrez gene - 68077     See in Manteia.
MGI - MGI:2154441
RefSeq - NM_133831
RefSeq Peptide - NP_598592
swissprot - Q8BK35
Ensembl - ENSMUSG00000041560
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nop53ENSDARG00000100452Danio rerio
 NOP53ENSG00000105373Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011687  Ribosome biogenesis protein Nop53/GLTSCR2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000027 ribosomal large subunit assembly IEA
 biological_processGO:0000055 ribosomal large subunit export from nucleus IBA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IEA
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0031333 negative regulation of protein complex assembly IEA
 biological_processGO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0039535 regulation of RIG-I signaling pathway IEA
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator IEA
 biological_processGO:1901797 negative regulation of signal transduction by p53 class mediator IMP
 biological_processGO:1901837 negative regulation of transcription of nucleolar large rRNA by RNA polymerase I IEA
 biological_processGO:1902570 protein localization to nucleolus IMP
 biological_processGO:1903006 positive regulation of protein K63-linked deubiquitination IEA
 biological_processGO:1903715 regulation of aerobic respiration IEA
 biological_processGO:1990173 protein localization to nucleoplasm IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISS
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0033553 rDNA heterochromatin IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008097 5S rRNA binding IEA
 molecular_functionGO:0019843 rRNA binding IBA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Phc1tm1Os/Phc1tm1Os,Tg(Myh7-Phc1)#Yota/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Nop53tm2.1Asuz/Nop53tm2.1Asuz,Tg(Lck-cre)#Jxm/0
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * CBA

Allelic Composition: Nop53tm2.1Asuz/Nop53tm2.1Asuz,Tg(Lck-cre)#Jxm/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: Phc1tm1Os/Phc1tm1Os,Tg(Myh7-Phc1)#Yota/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0020438 decreased papilloma incidence "fewer than the expected number of benign tumors consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells occurring in a specific population in a given time period" [MPATH:445]
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Allelic Composition: Nop53tm2.1Asuz/Nop53tm2.1Asuz,Tg(Lck-cre)#Jxm/0,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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