ENSMUSG00000041567


Mus musculus

Features
Gene ID: ENSMUSG00000041567
  
Biological name :Serpina12
  
Synonyms : Q7TMF5 / Serpin A12 / Serpina12
  
Possible biological names infered from orthology : Q8IW75 / serpin family A member 12
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: E
Gene start: 104028769
Gene end: 104044443
  
Corresponding Affymetrix probe sets: 10402428 (MoGene1.0st)   1421091_at (Mouse Genome 430 2.0 Array)   1421092_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045572
NCBI entrez gene - 68054     See in Manteia.
MGI - MGI:1915304
RefSeq - NM_026535
RefSeq Peptide - NP_080811
swissprot - Q7TMF5
Ensembl - ENSMUSG00000041567
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpina1ENSDARG00000090286Danio rerio
 serpina1lENSDARG00000090850Danio rerio
 serpina7ENSDARG00000087143Danio rerio
 si:ch211-186e20.2ENSDARG00000074712Danio rerio
 si:ch211-186e20.7ENSDARG00000077960Danio rerio
 zgc:174259ENSDARG00000091136Danio rerio
 ENSGALG00000028598Gallus gallus
 ENSGALG00000046409Gallus gallus
 ENSGALG00000020390Gallus gallus
 ENSGALG00000020388Gallus gallus
 SPIA1ENSGALG00000023070Gallus gallus
 SPIA4ENSGALG00000010969Gallus gallus
 Q8IW75ENSG00000165953Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Serpina3n / serine (or cysteine) peptidase inhibitor, clade A, member 3N / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000002109137
P22599 / Serpina1b / serine (or cysteine) preptidase inhibitor, clade A, member 1B / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000007117837
Serpina1c / serine (or cysteine) peptidase inhibitor, clade A, member 1C / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000007901537
P07758 / Serpina1a / serine (or cysteine) peptidase inhibitor, clade A, member 1A / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000006636637
P29621 / Serpina3c / Serine protease inhibitor A3C / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000006636136
Q00898 / Serpina1e / serine (or cysteine) peptidase inhibitor, clade A, member 1E / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000007284936
Q00897 / Serpina1d / serine (or cysteine) peptidase inhibitor, clade A, member 1D / P01009* / SERPINA1* / serpin family A member 1*ENSMUSG0000007117736
Q03734 / Serpina3m / Serine protease inhibitor A3M / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000007901235
Q80X76 / Serpina3f / Serine protease inhibitor A3F / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000006636335
Serpina3k / serine (or cysteine) peptidase inhibitor, clade A, member 3K / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000005820734
Serpina3i / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000007901433
Serpina7 / serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 / P05543* / serpin family A member 7*ENSMUSG0000003127132
Q6P4P1 / Serpina3a / serine (or cysteine) peptidase inhibitor, clade A, member 3A / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000004153632
Q9D7D2 / Serpina9 / serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 / Q86WD7* / serpin family A member 9*ENSMUSG0000005826032
Serpina11 / serpin family A member 11 / Q86U17*ENSMUSG0000006323231
Serpina3j / serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000007901331
Q8BYY9 / Serpina3b / serine (or cysteine) peptidase inhibitor, clade A, member 3B / P01011* / SERPINA3* / serpin family A member 3*ENSMUSG0000006636431
P70458 / Serpina5 / serine (or cysteine) peptidase inhibitor, clade A, member 5 / P05154* / serpin family A member 5*ENSMUSG0000004155031
Q06770 / Serpina6 / serine (or cysteine) peptidase inhibitor, clade A, member 6 / P08185* / serpin family A member 6*ENSMUSG0000006080730
Q8R121 / Serpina10 / Protein Z-dependent protease inhibitor / Q9UK55* / serpin family A member 10*ENSMUSG0000006194729


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0045721 negative regulation of gluconeogenesis IDA
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway IMP
 biological_processGO:0051055 negative regulation of lipid biosynthetic process IDA
 biological_processGO:0090181 regulation of cholesterol metabolic process IMP
 biological_processGO:0090207 regulation of triglyceride metabolic process IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
Show

Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems

 MP:0009288 increased epididymal fat pad weight 
Show

Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm367a(Ple251-icre/ERT2)Ems/Y
Genetic Background: B6.Cg-Hprttm367a(Ple251-icre/ERT2)Ems

Allelic Composition: Serpina12tm1Jwada/Serpina12+
Genetic Background: B6JJcl.129P2-Serpina12tm1Jwada

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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