Manteia - Molecule gene

ENSMUSG00000061947

Mus musculus

Features

Gene ID:	ENSMUSG00000061947

Biological name :	Serpina10

Synonyms :	Protein Z-dependent protease inhibitor / Q8R121 / Serpina10

Possible biological names infered from orthology :	Q9UK55 / serpin family A member 10

Species:	Mus musculus

Chr. number:	12
Strand:	-1
Band:	E
Gene start:	103614786
Gene end:	103631444

Corresponding Affymetrix probe sets:	10402360 (MoGene1.0st) 1424758_s_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000048357 Ensembl peptide - ENSMUSP00000113644 NCBI entrez gene - 217847 See in Manteia. MGI - MGI:2667725 RefSeq - NM_001301404 RefSeq - NM_144834 RefSeq Peptide - NP_001288333 RefSeq Peptide - NP_659083 swissprot - Q8R121 Ensembl - ENSMUSG00000061947

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
serpina10a	ENSDARG00000005924	Danio rerio
si:ch1073-416d2.3	ENSDARG00000036968	Danio rerio
SERPINA10	ENSGALG00000020391	Gallus gallus
Q9UK55	ENSG00000140093	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
P22599 / Serpina1b / serine (or cysteine) preptidase inhibitor, clade A, member 1B / P01009* / SERPINA1* / serpin family A member 1*	ENSMUSG00000071178	29
Q00898 / Serpina1e / serine (or cysteine) peptidase inhibitor, clade A, member 1E / P01009* / SERPINA1* / serpin family A member 1*	ENSMUSG00000072849	29
Serpina1c / serine (or cysteine) peptidase inhibitor, clade A, member 1C / P01009* / SERPINA1* / serpin family A member 1*	ENSMUSG00000079015	29
Serpina3i / P01011* / SERPINA3* / serpin family A member 3*	ENSMUSG00000079014	28
Serpina3k / serine (or cysteine) peptidase inhibitor, clade A, member 3K / P01011* / SERPINA3* / serpin family A member 3*	ENSMUSG00000058207	28
P07758 / Serpina1a / serine (or cysteine) peptidase inhibitor, clade A, member 1A / P01009* / SERPINA1* / serpin family A member 1*	ENSMUSG00000066366	28
P49182 / Serpind1 / serine (or cysteine) peptidase inhibitor, clade D, member 1 / P05546* / serpin family D member 1*	ENSMUSG00000022766	28
Q80X76 / Serpina3f / Serine protease inhibitor A3F / P01011* / SERPINA3* / serpin family A member 3*	ENSMUSG00000066363	28
Q00897 / Serpina1d / serine (or cysteine) peptidase inhibitor, clade A, member 1D / P01009* / SERPINA1* / serpin family A member 1*	ENSMUSG00000071177	28
Serpina3n / serine (or cysteine) peptidase inhibitor, clade A, member 3N / P01011* / SERPINA3* / serpin family A member 3*	ENSMUSG00000021091	27
Q03734 / Serpina3m / Serine protease inhibitor A3M / P01011* / SERPINA3* / serpin family A member 3*	ENSMUSG00000079012	27
P70458 / Serpina5 / serine (or cysteine) peptidase inhibitor, clade A, member 5 / P05154* / serpin family A member 5*	ENSMUSG00000041550	27
Serpina7 / serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 / P05543* / serpin family A member 7*	ENSMUSG00000031271	26
P29621 / Serpina3c / Serine protease inhibitor A3C / P01011* / SERPINA3* / serpin family A member 3*	ENSMUSG00000066361	26
Q9D7D2 / Serpina9 / serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 / Q86WD7* / serpin family A member 9*	ENSMUSG00000058260	26
Q7TMF5 / Serpina12 / Serpin A12 / Q8IW75* / serpin family A member 12*	ENSMUSG00000041567	26
Q6P4P1 / Serpina3a / serine (or cysteine) peptidase inhibitor, clade A, member 3A / P01011* / SERPINA3* / serpin family A member 3*	ENSMUSG00000041536	25
Serpina3j / serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3J / P01011* / SERPINA3* / serpin family A member 3*	ENSMUSG00000079013	25
Q8BYY9 / Serpina3b / serine (or cysteine) peptidase inhibitor, clade A, member 3B / P01011* / SERPINA3* / serpin family A member 3*	ENSMUSG00000066364	24
Serpina11 / serpin family A member 11 / Q86U17*	ENSMUSG00000063232	24

Protein motifs (from Interpro)

Interpro ID	Name
IPR000215	Serpin family
IPR023796	Serpin domain
IPR036186	Serpin superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0007596	blood coagulation	IEA
biological_process	GO:0007599	hemostasis	IEA
biological_process	GO:0010466	negative regulation of peptidase activity	IEA
biological_process	GO:0010951	negative regulation of endopeptidase activity	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IBA
molecular_function	GO:0004867	serine-type endopeptidase inhibitor activity	IBA
molecular_function	GO:0008201	heparin binding	IEA
molecular_function	GO:0030414	peptidase inhibitor activity	IEA

Pathways (from Reactome)

Pathway description

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Post-translational protein phosphorylation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001915	intracranial hemorrhage	"bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Atp7a^Mo-pew/Y Genetic Background: CBA/J-Atp7a^Mo-pew
MP:0005435	hemoperitoneum	"blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]	Show Allelic Composition: Atp7a^Mo-pew/Y Genetic Background: CBA/J-Atp7a^Mo-pew
MP:0006066	decreased clearance of atrial thrombosis	"slower removal of a thrombus from the atria of the heart" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Atp7a^Mo-pew/Y Genetic Background: CBA/J-Atp7a^Mo-pew
MP:0008770	decreased survivor rate	"a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atp7a^Mo-pew/Y Genetic Background: CBA/J-Atp7a^Mo-pew Allelic Composition: F5^tm2Dgi/F5^tm2Dgi,Serpina10^tm1Gjb/Serpina10^tm1Gjb Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 Allelic Composition: F5^tm2Dgi/F5⁺,Serpina10^tm1Gjb/Serpina10^tm1Gjb Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Atp7a^Mo-pew/Y Genetic Background: CBA/J-Atp7a^Mo-pew

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr